©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 28, 2017; 9(24): 1030-1039
Published online Aug 28, 2017. doi: 10.4254/wjh.v9.i24.1030
Published online Aug 28, 2017. doi: 10.4254/wjh.v9.i24.1030
Novel synthetic adhesive as an effective alternative to Fibrin based adhesives
Pramod Kadaba Srinivasan, Vera Sperber, Mamdouh Afify, Hirokazu Tanaka, Kenji Fukushima, Babette Kögel, René Tolba, Institute for Laboratory Animal Science and Experimental Surgery, University Hospital, RWTH Aachen, 52074 Aachen, Germany
Felix Gremse, Experimental Molecular Imaging, University Hospital, RWTH Aachen, 52074 Aachen, Germany
Author contributions: Srinivasan PK and Sperber V contributed equally to this paper; Srinivasan PK, Sperber V and Tolba R contributed to study concept and design; Srinivasan PK and Sperber V contributed to acquisition of data; Tolba R, Srinivasan PK, Sperber V, Gremse F and Afify M contributed to analysis and interpretation of data; Srinivasan PK and Sperber V contributed to drafting of the manuscript; Tolba R, Srinivasan PK, Tanaka H and Fukushima K contributed to critical revision of the manuscript for important intellectual content; Tolba R and Srinivasan PK contributed to statistical analysis; Gremse F and Kögel B contributed to administrative, technical and material support; Tolba R, Srinivasan PK, Sperber V and Kögel B contributed to study supervision.
Institutional review board statement: The governmental care and use committee (LANUV), Recklinghausen, NRW, Germany, granted official permission.
Conflict-of-interest statement: MAR-1 in this study was provided by Adhesys Medical GmbH. Pramod Kadaba Srinivasan is employed as a part-time researcher at Adhesys Medical GmbH and Adhesys Medical GmbH will cover the publication costs; Vera Sperber has no conflict of interest; Mamdouh Afify has no conflict of interest; Hirokazu Tanaka has no conflict of interest; Kenji Fukushima has no conflict of interest; Babette Kögel has no conflict of interest; Felix Gremse has no conflict of interest; René Tolba is a shareholder of Adhesys Medical GmbH.
Data sharing statement: No additional data are available.
Correspondence to: Dr. René Tolba, Professor, Director, Institute for Laboratory Animal Science and Experimental Surgery, University Hospital, RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany. rtolba@ukaachen.de
Telephone: +49-241-8088606
Received: March 30, 2017
Peer-review started: March 31, 2017
First decision: May 9, 2017
Revised: June 26, 2017
Accepted: July 7, 2017
Article in press: July 10, 2017
Published online: August 28, 2017
Processing time: 147 Days and 8.2 Hours
Peer-review started: March 31, 2017
First decision: May 9, 2017
Revised: June 26, 2017
Accepted: July 7, 2017
Article in press: July 10, 2017
Published online: August 28, 2017
Processing time: 147 Days and 8.2 Hours
Core Tip
Core tip: This study evaluates the effectiveness of a novel, polyurethane based, surgical adhesive on a liver resection model. This study will further help in better sealing of wounds in a trauma model in comparison to Fibrin glue.