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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 8, 2015; 7(16): 1974-1981
Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.1974
Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.1974
Role of systemic inflammation in cirrhosis: From pathogenesis to prognosis
Melisa Dirchwolf, Hepatopatías Infecciosas, Hospital Francisco J Muñiz, Buenos Aires 1282, Argentina
Andrés Eduardo Ruf, Fundación para la Docencia e Investigación de las Enfermedades del Hígado (FUNDIEH), Buenos Aires 1282, Argentina
Andrés Eduardo Ruf, Liver Transplant Unit, British Hospital of Buenos Aires, Buenos Aires 1280, Argentina
Author contributions: Dirchwolf M was involved in the study design, performed the required research, writing of the draft of the manuscript and approved its final version; Ruf AE was involved in the study design, writing and critical revision of the manuscript and approved its final version.
Conflict-of-interest statement: None of the authors have received fees for serving as a speaker or consultant, nor have they received financial or non-financial support related to this manuscript. The authors have no commercial, personal, political, intellectual, or religious interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Andrés Eduardo Ruf, MD, Liver Transplant Unit, British Hospital of Buenos Aires, Perdriel 74, Buenos Aires 1280, Argentina. aeruf@hotmail.com
Telephone: +54-011-43096545 Fax: +54-011-43096545
Received: May 15, 2015
Peer-review started: May 16, 2015
First decision: June 3, 2015
Revised: June 15, 2015
Accepted: June 30, 2015
Article in press: July 2, 2015
Published online: August 8, 2015
Processing time: 85 Days and 3 Hours
Peer-review started: May 16, 2015
First decision: June 3, 2015
Revised: June 15, 2015
Accepted: June 30, 2015
Article in press: July 2, 2015
Published online: August 8, 2015
Processing time: 85 Days and 3 Hours
Core Tip
Core tip: Due to the overwhelming evidence that sustains systemic inflammation influences the natural history of cirrhosis, a review of its current prognostic markers is necessary to highlight their strengths and weaknesses and stimulate further clinical research on this subject.