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World J Hepatol. Mar 27, 2026; 18(3): 115108
Published online Mar 27, 2026. doi: 10.4254/wjh.v18.i3.115108
Published online Mar 27, 2026. doi: 10.4254/wjh.v18.i3.115108
Predicting pancreatic fistula post-splenectomy in cirrhosis with splenomegaly: Risk factors and nomogram validation
Long Huang, Qi Zhang, Department of Hepatobiliary Surgery, The First Hospital Affiliated to Anhui University of Traditional Chinese Medicine, Hefei 230031, Anhui Province, China
Qing-Lin Li, Key Laboratory of Xin’an Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230031, Anhui Province, China
Qing-Sheng Yu, Hui Peng, Department of Hepatobiliary Surgery, Anhui University of Tra
Zhou Zhen, Department of Surgery, The Second Hospital Affiliated to Anhui University of Traditional Chinese Medicine, Hefei 230061, Anhui Province, China
Yi Shen, Department of Surgery, Anhui University of Traditional Chinese Medicine, Hefei 230031, Anhui Province, China
Author contributions: Huang L contributed to funding acquisition, project administration, writing-original draft preparation; Li QL contributed to conceptualization, methodology; Yu QS contributed to investigation, data curation; Peng H contributed to reviewing and editing; Zhen Z contributed to formal analysis; Zhang Q contributed to validation; Shen Y contributed to software operation. All authors have reviewed the manuscript.
Supported by Projects of Anhui Provincial Health Commission, No. AHWJ2023A30146; Scientific Research Projects in Anhui Provincial Colleges and Universities, No. 2024AH050959; and the Anhui Provincial Natural Science Foundation, No. 2408085MH222.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital of the Anhui University of Chinese Medicine, approval No. 2024AH-30.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: If you request data for this study, please contact the corresponding author (Long Huang,
Corresponding author: Long Huang, MD, Chief Doctor, Professor, Department of Hepatobiliary Surgery, The First Hospital Affiliated to Anhui University of Traditional Chinese Medicine, No. 117 Meishan Road, Hefei 230031, Anhui Province, China. huanglong658@163.com
Received: October 13, 2025
Revised: November 10, 2025
Accepted: January 7, 2026
Published online: March 27, 2026
Processing time: 169 Days and 17.7 Hours
Revised: November 10, 2025
Accepted: January 7, 2026
Published online: March 27, 2026
Processing time: 169 Days and 17.7 Hours
Core Tip
Core Tip: This retrospective study included 186 cirrhotic patients with splenomegaly who underwent splenectomy. Through multivariate least absolute shrinkage and selection operator-penalized logistic regression, body mass index and splenic thickness were confirmed as independent risk factors for clinically relevant postoperative pancreatic fistula. The nomogram built on these factors achieved an area under the receiver operating characteristic curve of 0.816, providing reliable individualized perioperative risk prediction to cut clinically relevant postoperative pancreatic fistula occurrence and boost patient recovery.