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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2026; 18(2): 114551
Published online Feb 27, 2026. doi: 10.4254/wjh.v18.i2.114551
Published online Feb 27, 2026. doi: 10.4254/wjh.v18.i2.114551
Ginger as a nutraceutical shield: Counteracting acrylamide-induced liver injury
Alberto Massimi, Mara Massimi, Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila 67100, AQ, Italy
Author contributions: Massimi M conceived the overall concept and outline, drafted the manuscript, and supervised the work; Massimi A prepared the figure and the table, and contributed to the discussion and literature review. All authors critically revised the manuscript and approved the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mara Massimi, PhD, Associate Professor, Department of Life, Health and Environmental Sciences, University of L’Aquila, Via Vetoio, L’Aquila 67100, AQ, Italy. mara.massimi@univaq.it
Received: September 23, 2025
Revised: October 23, 2025
Accepted: January 4, 2026
Published online: February 27, 2026
Processing time: 143 Days and 2.9 Hours
Revised: October 23, 2025
Accepted: January 4, 2026
Published online: February 27, 2026
Processing time: 143 Days and 2.9 Hours
Core Tip
Core Tip: Acrylamide, a common food contaminant, contributes to liver injury through oxidative and inflammatory mechanisms. Nour El Deen et al demonstrate that a standardized ginger extract (≥ 20% 6-gingerol) protects against acrylamide-induced hepatotoxicity in rats. The editorial highlights the broader implications of such findings: Standardized nutraceuticals can serve as accessible tools for preventive hepatology. Within a precision-nutrition context, rigorous compositional and molecular validation will be essential to translate these preclinical observations into human relevance.