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Publication Name
World Journal of Hepatology
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1948-5182
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2026; 18(1): 114384
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.114384
Multidrug-resistant organism colonization in critically ill cirrhotic patients: Marker or mediator of mortality?
Shi-San Bao, Yan Lu
Shi-San Bao, Department of Pathology, Faculty of Medicine and Health, University of Sydney, Sydney 2006, New South Wales, Australia
Yan Lu, Department of Clinical Laboratory, Gansu Provincial Hospital of TCM, Lanzhou 730050, Gansu Province, China
Co-corresponding authors: Shi-San Bao and Yan Lu.
Author contributions: Bao SS and Lu Y drafted and revised the manuscript, and they contributed equally to this manuscript as co-corresponding authors. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shi-San Bao, Department of Pathology, Faculty of Medicine and Health, University of Sydney, D06, Sydney 2006, New South Wales, Australia. profbao@hotmail.com
Received: September 17, 2025
Revised: October 1, 2025
Accepted: December 17, 2025
Published online: January 27, 2026
Processing time: 131 Days and 19.7 Hours
Core Tip

Core Tip: Multidrug-resistant organism colonization is frequent in critically ill cirrhotic patients and strongly predicts subsequent infection. However, colonization alone does not determine mortality, which is primarily driven by organ dysfunction severity. Colonization status remains an important tool for guiding empiric antimicrobial therapy and tailoring stewardship strategies, particularly in regions with distinct epidemiological patterns.
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