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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2026; 18(1): 111722
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.111722
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.111722
Application of modified Charlson comorbidity index for predicting outcomes following adult living donor liver transplantation
Gowtham Rajan, Department of Liver Anaesthesiology and Critical Care, Dr. Rela Institute, Chennai 600044, Tamil Nadu, India
Amal Francis Sam, Department of Liver Anaesthesiology and Critical Care, Institute of Liver Disease and Transplantation, Chennai 600044, Tamil Nadu, India
Akila Rajakumar, Department of Liver Transplant Anaesthesia and Intensive Care, Institute of Liver Disease and Transplantation, Dr. Rela Institute, Chennai 600044, Tamil Nadu, India
Dinesh Jothimani, Department of Hepatology, Dr. Rela Institute, Chennai 600044, Tamil Nadu, India
Mohamed Rela, Institute of Liver Disease and Transplantation, Dr. Rela Institute and Medical Centre, Chennai 600044, Tamil Nadu, India
Co-first authors: Gowtham Rajan and Amal Francis Sam.
Author contributions: Rajan G and Sam AF were responsible for conceptualization of methodology and conducting the study, data curation, and formal analysis as co-first authors; Rajakumar A was responsible for conceptualization, formal analysis, supervision, validation, and original draft preparation; Jothimani D and Rela M were responsible for supervision, writing, review, and editing; all of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: The study was reviewed and approved by the Institutional Ethics committee, No. ECR/1276/Inst/TN/2019/2025/312.
Informed consent statement: Being a retrospective study, informed consent was waived by the Institutional Ethics Committee, No. ECR/1276/Inst/TN/2019/2025/312.
Conflict-of-interest statement: The authors do not have any conflicts of interest to disclose.
Data sharing statement: The data is available upon reasonable request from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Akila Rajakumar, MD, FRCA, Head, Department of Liver Transplant Anaesthesia and Intensive Care, Institute of Liver Disease and Transplantation, Dr. Rela Ins
Received: July 8, 2025
Revised: August 29, 2025
Accepted: November 24, 2025
Published online: January 27, 2026
Processing time: 203 Days and 16 Hours
Revised: August 29, 2025
Accepted: November 24, 2025
Published online: January 27, 2026
Processing time: 203 Days and 16 Hours
Core Tip
Core Tip: With advances in surgical techniques and perioperative care, the outcomes of liver transplantation have improved significantly, encouraging its use in more elderly patients and those with more comorbidities. In addition to liver disease severity, understanding the impact of extra-hepatic comorbidities on the outcomes will help in prognostication and risk stratification with appropriate resource planning. The Charlson comorbidity index has been validated as a good predictor of long-term survival in varied clinical populations. With limited studies regarding its use in liver transplant patients, we aimed to study its applicability in a cohort of living donor liver transplant patients.