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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2025; 17(9): 110128
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110128
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110128
Gender disparities in hepatitis C treatment: A call for tailored approaches
Eyad Gadour, Multiorgan Transplant Centre of Excellence, Liver Transplantation Unit, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia
Eyad Gadour, Faculty of Medicine, Zamzam University College, Khartoum 11113, Sudan
Author contributions: Gadour E, is the sole author of this manuscript. He conceptualized the Letter, conducted the literature review and wrote the manuscript.
Conflict-of-interest statement: The author has no conflict of interest related to the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eyad Gadour, CCST, Consultant, FACP, FRCP, MRCP, Professor, Multiorgan Transplant Centre of Excellence, Liver Transplantation Unit, King Fahad Specialist Hospital, Ammar Bin Thabit Street, Dammam 32253, Saudi Arabia.
Received: May 30, 2025
Revised: June 15, 2025
Accepted: August 4, 2025
Published online: September 27, 2025
Processing time: 119 Days and 6 Hours
Revised: June 15, 2025
Accepted: August 4, 2025
Published online: September 27, 2025
Processing time: 119 Days and 6 Hours
Core Tip
Core Tip: Recent research has revealed significant sex disparities in hepatitis C treatment outcomes. Women, particularly premenopausal and menopausal women, show higher sustained virologic response rates than men. However, postmenopausal women face unique challenges. This highlights the need for sex-sensitive approaches in hepatitis C management, considering biological, hormonal, and psychosocial factors. Healthcare providers should implement tailored treatment strategies to address such disparities, improve patient outcomes, and ensure equitable care. Further research is needed to explore the underlying mechanisms driving these differences, ultimately contributing to more effective and personalized care across diverse demographics.