Gender disparities in hepatitis C treatment: A call for tailored approaches

doi:10.4254/wjh.v17.i9.110128

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Sep 27, 2025 (publication date) through Mar 18, 2026

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Hepatol. Sep 27, 2025; 17(9): 110128
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110128

Gender disparities in hepatitis C treatment: A call for tailored approaches

Eyad Gadour

Eyad Gadour, Multiorgan Transplant Centre of Excellence, Liver Transplantation Unit, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia

Eyad Gadour, Faculty of Medicine, Zamzam University College, Khartoum 11113, Sudan

Author contributions: Gadour E, is the sole author of this manuscript. He conceptualized the Letter, conducted the literature review and wrote the manuscript.

Conflict-of-interest statement: The author has no conflict of interest related to the manuscript.

Corresponding author: Eyad Gadour, CCST, Consultant, FACP, FRCP, MRCP, Professor, Multiorgan Transplant Centre of Excellence, Liver Transplantation Unit, King Fahad Specialist Hospital, Ammar Bin Thabit Street, Dammam 32253, Saudi Arabia. eyadgadour@doctors.org.uk

Received: May 30, 2025
Revised: June 15, 2025
Accepted: August 4, 2025
Published online: September 27, 2025
Processing time: 119 Days and 6 Hours

Core Tip

Core Tip: Recent research has revealed significant sex disparities in hepatitis C treatment outcomes. Women, particularly premenopausal and menopausal women, show higher sustained virologic response rates than men. However, postmenopausal women face unique challenges. This highlights the need for sex-sensitive approaches in hepatitis C management, considering biological, hormonal, and psychosocial factors. Healthcare providers should implement tailored treatment strategies to address such disparities, improve patient outcomes, and ensure equitable care. Further research is needed to explore the underlying mechanisms driving these differences, ultimately contributing to more effective and personalized care across diverse demographics.