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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2025; 17(9): 110049
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110049
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110049
Albumin-bilirubin score reflects the extent of liver fibrosis in chronic hepatitis C patients treated with direct-acting antivirals
Mohammed Ewid, Department of Internal Medicine, College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah 51941, Qassim, Saudi Arabia
Mohammed Ewid, Amro Abdelaziz Mohammed Ismail, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo 11562, Egypt
Hossam Sherif, Department of Critical Care Medicine, College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah 51941, Qassim, Saudi Arabia
Hossam Sherif, Department of Critical Care Medicine, Cairo University, Cairo 11562, Egypt
Nazmus Saquib, Department of Epidemiology, College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah 51941, Qassim, Saudi Arabia
Ammar Mohammed Alammari, Amro Abdelaziz Mohammed Ismail, Nawaf Al Mutiri, Department of Gastroenterology, King Fahad Specialist Hospital, Buraydah 52366, Qassim, Saudi Arabia
Mohammed H Alkahlot, Ziyad T Ahmed, Faisal Zain Mohammed Al-Zabidi, College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah 51941, Qassim, Saudi Arabia
Author contributions: Ewid M, Sherif H, Saquib N, and Al-Zabidi FZM completed the statistical analysis, and interpreted the data; Ewid M and Saquib N critically revised the manuscript; Ewid M, Saquib N, Alkahlot MH, Ahmed ZT, and Al Mutiri N designed the study; Alammari AM, Ismail AAM, and Al Mutiri N provided administrative support; Alkahlot MH, Ahmed ZT, and Al-Zabidi FZM provided technical or material support.
Institutional review board statement: This study was conducted in accordance with ethical principles that have their origin in the provisions of the Declaration of Helsinki. Ethical approval was granted by the Regional Research Ethics Committee - Qassim Province, Ministry of Health, Saudi Arabia (Approval No. 1441-667587).
Informed consent statement: The requirement for participants to consent to participate was waived by the Regional Research Ethics Committee as the study was retrospective.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The dataset supporting the conclusions of this article is available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Ewid, MD, Department of Internal Medicine, College of Medicine, Sulaiman Al Rajhi University, Post Office Box 777, Al Bukayriyah 51941, Qassim, Saudi Arabia. drmohammedowid@gmail.com
Received: May 30, 2025
Revised: June 25, 2025
Accepted: August 15, 2025
Published online: September 27, 2025
Processing time: 118 Days and 19.3 Hours
Revised: June 25, 2025
Accepted: August 15, 2025
Published online: September 27, 2025
Processing time: 118 Days and 19.3 Hours
Core Tip
Core Tip: The albumin-bilirubin score is a simple and reproducible score that showed significant improvement following direct-acting antivirals treatment in patients with chronic hepatitis C virus infection. Moreover, it predicted advanced liver fibrosis with a sensitivity of 60% and a specificity of 83% at a cut-off value of -2.38. Accordingly, it could be utilized to monitor liver function and to determine the extent of liver fibrosis among those patients.