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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2025; 17(9): 109118
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.109118
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.109118
Stratification and selection of therapies to improve survival in severe alcoholic hepatitis
Ajay Kumar Mishra, Amit Goel, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Author contributions: Mishra AK wrote the manuscript; Goel A supervised and edited the manuscript.
Conflict-of-interest statement: The authors declare that they have no affiliations with or involvement in any organization or entity with any financial interest in the subject matter or materials discussed in this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amit Goel, Professor, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. agoel.ag@gmail.com
Received: April 30, 2025
Revised: May 21, 2025
Accepted: August 8, 2025
Published online: September 27, 2025
Processing time: 149 Days and 2.5 Hours
Revised: May 21, 2025
Accepted: August 8, 2025
Published online: September 27, 2025
Processing time: 149 Days and 2.5 Hours
Core Tip
Core Tip: Clinically, severe alcoholic hepatitis (SAH) presents with jaundice, with or without ascites or encephalopathy, and it progresses rapidly. The patient population is heterogeneous and needs to be stratified according to their eligibility for specific therapies. Emerging alternatives or rescue therapies are available for SAH. The decision for the preferred therapy is based on patient profile, clinical experiences, and its side effects profile. This comprehensive review provides insight into the stratification of patients who need specific therapies, with the primary focus on the therapies that improve survival in SAH.