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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2025; 17(9): 108259
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.108259
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.108259
Extracellular vesicles in metabolic dysfunction-associated steatotic liver disease: From intercellular signaling to clinical translation
Bootsakorn Boonkaew, Denita Charoenthanakitkul, Nuchanart Suntornnont, Chaiyaboot Ariyachet, Pisit Tangkijvanich, Department of Biochemistry, Faculty of Medicine, Chula
Bootsakorn Boonkaew, Denita Charoenthanakitkul, Nuchanart Suntornnont, Chaiyaboot Ariyachet, Pisit Tangkijvanich, Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Author contributions: Boonkaew B and Ariyachet C conceptualized the study and reviewed and edited the various versions of the paper; Boonkaew B, Charoenthanakitkul D, and Ariyachet C wrote the original draft of the paper; Suntornnont N generated the data visualization images; Tangkijvanich P supervised the project; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chaiyaboot Ariyachet, Assistant Professor, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Paettayaphat Bldg, Rama IV Road, Bangkok 10330, Thailand. chaiyaboot.a@chula.ac.th
Received: April 9, 2025
Revised: May 18, 2025
Accepted: August 13, 2025
Published online: September 27, 2025
Processing time: 169 Days and 18.5 Hours
Revised: May 18, 2025
Accepted: August 13, 2025
Published online: September 27, 2025
Processing time: 169 Days and 18.5 Hours
Core Tip
Core Tip: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern that progresses from simple steatosis to cirrhosis. Extracellular vesicles (EVs) have emerged as key mediators of MASLD pathogenesis, influencing lipotoxicity, inflammation, and fibrosis through bioactive cargoes such as microRNAs. This review highlights the role of EVs in MASLD progression, their diagnostic and prognostic potential, and EV-based therapeutic strategies. We also address current challenges, emerging research trends, and future perspectives, emphasizing the translational potential of EVs for improving patient outcomes.