Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2025; 17(9): 107806
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.107806
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.107806
Anti-hepatitis B virus effects of traditional Chinese medicine: Learning from clinical trials in the past twenty years
Xue Feng, Nan-Nan Li, Gui-Jian Liu, Cheng An, Chao Liu, Clinical Laboratory, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Co-corresponding authors: Cheng An and Chao Liu.
Author contributions: Feng X and Li NN performed a literature search and wrote the manuscript; Liu GJ, An C, and Liu C designed the study and revised the manuscript; An C and Liu C have played important and indispensable roles in the manuscript preparation as the co-corresponding authors; all of the authors read and approved the final version of the manuscript to be published.
Supported by The Funding of Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences, No. CI2021A00810; and The Escort Project of Guang’anmen Hosital, China Academy of Chinese Medical Science-Backbone Talent Cultivation Project, No. 9323013.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Liu, PhD, Associate Professor, Clinical Laboratory, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Bei Xiange Road, Beijing 100053, China. chaoliu26@126.com
Received: April 1, 2025
Revised: May 22, 2025
Accepted: July 29, 2025
Published online: September 27, 2025
Processing time: 180 Days and 21.4 Hours
Revised: May 22, 2025
Accepted: July 29, 2025
Published online: September 27, 2025
Processing time: 180 Days and 21.4 Hours
Core Tip
Core Tip: Over the past two decades, multicenter clinical studies and meta-analyses have demonstrated that traditional Chinese medicines (TCM) exhibit certain antiviral properties. When administered in conjunction with nucleoside drugs, TCM can elevate the negative conversion rates or decrease hepatitis B virus e antigen, hepatitis B virus (HBV) DNA, and HBV surface antigen, ultimately enhancing therapeutic outcomes. The underlying antiviral mechanisms may involve reducing the negative immune regulation, augmenting the host immune response, and increasing the levels of HBV-specific cytotoxic T lymphocytes.