Prospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 27, 2025; 17(5): 106916
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.106916
Assessing the role of Mac-2 binding protein glycosylation isomer in the management of patients with chronic hepatitis B
Thuy T T Pham, Dat T Ho, Hai T Phan, Toan B Nguyen, Khue M Nguyen
Thuy T T Pham, Dat T Ho, Department of Hepatology, Medic Medical Center, Ho Chi Minh 700000, Viet Nam
Hai T Phan, Department of Imaging Diagnostic, Medic Medical Center, Ho Chi Minh City 700000, Viet Nam
Toan B Nguyen, Department of Laboratory, Medic Medical Center, Ho Chi Minh 700000, Viet Nam
Khue M Nguyen, Department of Genetics, Ho Chi Minh University of Science, Ho Chi Minh 700000, Viet Nam
Khue M Nguyen, Department of Scientific Affairs, Sysmex Vietnam, Ho Chi Minh 700000, Viet Nam
Author contributions: Pham TTT, Ho DT contributed to conceptualization and design; Nguyen KM, Pham TTT, and Ho DT contributed to material preparation, data acquisition, and analysis; Nguyen TB managed laboratory test performance, logistics and adminstration; Nguyen KM developed draft manuscript; Phan HT managed the fibroscan technique and supevised adminstration; Pham TTT, Ho DT, and Nguyen KM contributed equally to this study; All authors contributed to writing-revision and approved to submit the final version.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Medic Medical Center (No: 03/2020/HDDD/YTHH, issued on August 24th 2020).
Informed consent statement: Waiver request for Informed Consent for study utilizing residual blood samples.
Conflict-of-interest statement: Khue Minh Nguyen is a Sysmex employee.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at minhkhuenguyen8888@gmail.com. No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khue M Nguyen, Research Fellow, Senior Researcher, Department of Genetics, Ho Chi Minh University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh 700000, Viet Nam. minhkhuenguyen8888@gmail.com
Received: March 11, 2025
Revised: April 7, 2025
Accepted: May 7, 2025
Published online: May 27, 2025
Processing time: 77 Days and 15.6 Hours
Core Tip

Core Tip: The study highlights the innovative use of the Mac-2 binding protein glycosylated isomer (M2BPGi) as a non-invasive serum marker for assessing liver fibrosis in patients with chronic hepatitis B. It establishes specific cut-off values for M2BPGi to distinguish between significant fibrosis (F ≥ 2), advanced fibrosis (F3), and cirrhosis (F4). The research demonstrates a strong correlation between M2BPGi levels and transient elastography results, suggesting its reliability. Moreover, the study reveals M2BPGi’s potential in monitoring fibrosis regression during antiviral treatment, offering a valuable tool for clinical practice, particularly when advanced imaging options are unavailable.