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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 27, 2025; 17(5): 105769
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.105769
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.105769
Prognostic challenges in alcoholic hepatitis: From scoring systems to clinical predictors
Mariana M Ramírez-Mejía, Arnulfo E Morales-Galicia, Nahum Méndez-Sánchez, Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04360, Mexico
Nahum Méndez-Sánchez, Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City 14050, Mexico
Author contributions: Ramírez-Mejía MM, Morales-Galicia AE, and Méndez-Sánchez N contributed to the writing and editing of the manuscript, the illustrations, and the review of the literature; Ramírez-Mejía MM and Morales-Galicia AE contributed to the discussion and design of the manuscript; Méndez-Sánchez N designed the overall concept and outline of the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nahum Méndez-Sánchez, MD, PhD, Professor, Liver Research Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City 14050, Mexico. nmendez@medicasur.org.mx
Received: February 7, 2025
Revised: March 20, 2025
Accepted: March 20, 2025
Published online: May 27, 2025
Processing time: 110 Days and 5.9 Hours
Revised: March 20, 2025
Accepted: March 20, 2025
Published online: May 27, 2025
Processing time: 110 Days and 5.9 Hours
Core Tip
Core Tip: Prognostic scoring systems, particularly the Lille model, play a crucial role in the treatment of alcoholic hepatitis by facilitating the early identification of patients who do not respond to corticosteroid therapy. The study by Yang et al highlights the predictive value of Lille model 3-7 and underlines the importance of timely treatment adjustment to minimize complications. The study also highlights the impact of nutritional deficits and renal dysfunction on mortality, suggesting a multidisciplinary approach that integrates early nutritional interventions and nephroprotective strategies to improve patient outcomes.