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World J Hepatol. May 27, 2025; 17(5): 105582
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.105582
Gut feeling gone wrong: Tangled relationship between disorders of gut-brain interaction and liver disease
Manjeet Kumar Goyal, Prerna Goyal, Omesh Goyal, Ajit Sood
Manjeet Kumar Goyal, Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, Delhi, India
Prerna Goyal, Department of Medicine, R.G. Stone Super Speciality Hospital, Ludhiana 141001, Punjab, India
Omesh Goyal, Ajit Sood, Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India
Co-first authors: Manjeet Kumar Goyal and Prerna Goyal.
Author contributions: Goyal MK and Goyal O contributed to conceptualization; Goyal MK contributed to visualization; Goyal MK and Goyal P contributed to literature search, they contributed equally as co-first authors; Goyal O and Sood A contributed to supervision, validation, and visualization; Goyal MK, Goyal P, Goyal O, and Sood A contributed to writing original draft, reviewing and editing.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Omesh Goyal, Professor, Department of Gastroenterology, Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com
Received: January 30, 2025
Revised: April 3, 2025
Accepted: April 30, 2025
Published online: May 27, 2025
Processing time: 119 Days and 4.5 Hours
Core Tip

Core Tip: The review highlights the complex bidirectional relationship between disorders of gut-brain interaction and liver diseases, particularly cirrhosis. It emphasizes shared pathophysiological mechanisms such as gut dysbiosis, increased intestinal permeability, and neuroimmune dysregulation, which exacerbate clinical manifestations and complicate management. The article suggests integrative diagnostic approaches and therapeutic strategies targeting the gut microbiome and neuroimmune pathways to improve patient outcomes.