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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 27, 2025; 17(5): 103852
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.103852
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.103852
Association between weight fluctuation and the risk of metabolic dysfunction-associated steatotic liver disease
Jin-Ping Wang, Jia-Yang Wang, Pei-Qi Sun, Xue-Wei Wang, Ze-Ting Yuan, Qin Cao, Yuan-Ye Jiang, Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Shu-Ming Pan, Department of Emergency, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Co-first authors: Jin-Ping Wang and Jia-Yang Wang.
Co-corresponding authors: Yuan-Ye Jiang and Shu-Ming Pan.
Author contributions: Wang JP and Wang JY were responsible for software; Wang JP, Wang JY, Sun PQ, Wang XW, Yuan ZT and Cao Q were responsible for writing original draft; Wang JY, Sun PQ, Pan SM and Jiang YY were responsible for writing review editing; Wang JP, Wang JY and Yuan ZT were responsible for investigation; Wang JY and Sun PQ were responsible for visualization; Wang JP, Sun PQ, Wang XW and Cao Q were responsible for data curation; Jiang YY was responsible for funding acquisition and methodology; Pan SM and Jiang YY were responsible for project administration and supervision; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82474378; Shanghai Natural Science Foundation, No. 22ZR1455900; Shanghai Municipal Health Planning Commission Clinical Research Specialized Face Project, No. 201940449; Key Project of Science and Technology Innovation Program of Shanghai Putuo District Health and Health System, No. ptkwws202201; Reserve Excellent Chinese Medicine Talent Program of Shanghai University of Traditional Chinese Medicine, No. 20D-RC-02; Apricot Grove, Shanghai Putuo District Excellent Young Talent Training Program, No. ptxlyq2201; and Shanghai Putuo District Health and Health System Characteristic Specialty Disease Construction Project, No. 2023tszb01.
Institutional review board statement: The Institutional Ethical Review Board approved this study (No. PTEC-A-2024-28(S)-1).
Informed consent statement: As no direct participant contact or additional data collection occurred, no statement of informed consent is required.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: The original data presented in this study are available from the National Health and Nutrition Examination Survey database.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan-Ye Jiang, Deputy Chief Physician, Department of Gastroen
Received: December 6, 2024
Revised: March 24, 2025
Accepted: April 24, 2025
Published online: May 27, 2025
Processing time: 172 Days and 21.7 Hours
Revised: March 24, 2025
Accepted: April 24, 2025
Published online: May 27, 2025
Processing time: 172 Days and 21.7 Hours
Core Tip
Core Tip: The risk of metabolic dysfunction-associated steatotic liver disease (MASLD) increases with age in individuals transitioning from non-obese to obese or maintaining obesity. High-intensity physical activity is beneficial in reducing the risk of MASLD among individuals with stable obesity. Delineation of the dose-response relationship between weight fluctuation patterns and MASLD prevalence risk will facilitate the development of personalized exercise prescriptions.