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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2025; 17(12): 110303
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110303
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110303
Clinical and biological significance of the relationship between gut microbiota and liver disease
Stanislav N Kotlyarov, Department of Nurse, Ryazan State Medical University, Ryazan 390005, Russia
Author contributions: Kotlyarov SN contributed to the conceptualization, methodology, validation, resources, data curation, preparation of the original draft, review and editing, supervision, and project administration.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stanislav N Kotlyarov, PhD, Head of the Department, Department of Nurse, Ryazan State Medical University, Russian Federation, Ryazan, Vysokovoltnaya, 9, Ryazan 390005, Russia. skmr1@yandex.ru
Received: June 4, 2025
Revised: July 16, 2025
Accepted: November 12, 2025
Published online: December 27, 2025
Processing time: 205 Days and 22.8 Hours
Revised: July 16, 2025
Accepted: November 12, 2025
Published online: December 27, 2025
Processing time: 205 Days and 22.8 Hours
Core Tip
Core Tip: The gut microbiota has numerous metabolic and immune connections not only to the gut itself but also to other organs, including the lungs, brain, and liver. The gut-liver connection is bidirectional, and disruptions in this relationship contribute to the development of various liver diseases. Modulation of gut microbiota composition and function forms the basis of therapeutic strategies for conditions such as non-alcoholic fatty liver disease, cirrhosis, and hepatocellular carcinoma.