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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2025; 17(12): 110076
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110076
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110076
Interplay between intestinal permeability and metabolic dysfunction-associated steatotic liver disease: Could there be a role for extra virgin olive oil consumption?
Lydia Giannitrapani, Marinella Ferraro, Aurelio Seidita, Anna Licata, Maurizio Soresi, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo 90127, Sicilia, Italy
Lydia Giannitrapani, Institute for Biomedical Research and Innovation, National Research Council, Palermo 90146, Sicilia, Italy
Author contributions: Giannitrapani L and Soresi M conceptualised the study, created the artwork, supervised, and made critical revisions; Seidita A and Licata A performed the data analysis and interpretation; Ferraro M conducted the literature review and drafted the original manuscript; all authors prepared the draft and approved the submitted version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maurizio Soresi, MD, Associate Professor, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, Via del Vespro 141, Palermo 90127, Sicilia, Italy.
Received: May 28, 2025
Revised: July 23, 2025
Accepted: November 24, 2025
Published online: December 27, 2025
Processing time: 212 Days and 0.5 Hours
Revised: July 23, 2025
Accepted: November 24, 2025
Published online: December 27, 2025
Processing time: 212 Days and 0.5 Hours
Core Tip
Core Tip: Several studies have proven the close relationship between eating behaviour, intestinal permeability, and its influence on the “leaky gut” and the development of metabolic dysfunction-associated steatotic liver disease. This review aims to focus on the possible role of extra virgin olive oil consumption, as a fundamental component of the Mediterranean diet, on the gut-liver axis, with particular attention to its role as an antioxidant and anti-inflammatory functional food.