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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Nov 27, 2025; 17(11): 111576
Published online Nov 27, 2025. doi: 10.4254/wjh.v17.i11.111576
Published online Nov 27, 2025. doi: 10.4254/wjh.v17.i11.111576
Genetic predeterminants and recent advancements in steatotic liver disease: A roadmap toward precision hepatology
Ganesh Kumar, Department of Internal Medicine, Chandka Medical College, Sindh 77170, Pakistan
Yash R Shah, Manesh Kumar Gangwani, Ragesh B Thandassery, Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
Abeer Shahzad, Khadija Jameel, Department of Internal Medicine, Dow Medical College, Karachi 74200, Sindh, Pakistan
David Guevara-Lazo, Faculty of Medicine, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
Najia Ali Khan, Department of Internal Medicine, Khyber Medical College, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan
Dushyant Singh Dahiya, Division of Gastroenterology, Hepatology, and Motility, University of Kansas Medical Center, Kansas, KS 66160, United States
Rakshana Ravichandran, Ravi Patel, Department of Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, MI 48341, United States
Umar Hayat, Department of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkes Barre, PA 18711, United States
Ragesh B Thandassery, Department of Gastroenterology and Hepatology, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, United States
Co-first authors: Ganesh Kumar and Yash R Shah.
Author contributions: Shah YR, Kumar G, and Dahiya DS contributed to conception and design; Shah YR, Thandassery RB, and Dahiya DS contributed to administrative support; Shah YR, Kumar G, Shahzad A, Ravichandran R contributed to provision, collection, and assembly of data; Kumar G, Shah YR, Shahzad A, Jameel K, Guevara-Lazo D, Khan NA, Dahiya DS, Gangwani MK, Ravichandran R, Patel R and Hayat U contributed to review of literature and drafting the manuscript; Kumar G, Shahzad A, Jameel K, Guevara-Lazo D, Patel R, and Khan NA contributed to revision of key components of the manuscript; Kumar G, Shah YR, Dahiya DS, Gangwani MK, and Thandassery RB contributed to the final approval of manuscript. All authors have agreed to the final version of the manuscript. Kumar G and Shah YR contributed equally to this work as co-first authors.
Conflict-of-interest statement: The authors declare no conflicts of interest related to the content of this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yash R Shah, MD, Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, United States. yashu211996@gmail.com
Received: July 3, 2025
Revised: July 13, 2025
Accepted: October 30, 2025
Published online: November 27, 2025
Processing time: 147 Days and 4.3 Hours
Revised: July 13, 2025
Accepted: October 30, 2025
Published online: November 27, 2025
Processing time: 147 Days and 4.3 Hours
Core Tip
Core Tip: Steatotic liver disease (SLD) is a chronic disorder, characterized by the excessive accumulation of fat in the liver. It is the most common cause of cirrhosis and hepatocellular carcinoma. Many genetic factors including PNPLA3, TM6SF2, GCKR, MBOAT7, HSD17B14 etc., contribute to the development of the disease apart from the various metabolic and endocrine etiologies. Deciphering these genetic markers will help not only in the understanding of pathogenesis but can lead to the development of the various targeted therapies and diagnostic modalities. In this article, we review the genetic markers associated with the SLD, their ethnic distribution and implication in the therapeutic and diagnostic advancements.