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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 27, 2025; 17(10): 110029
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.110029
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.110029
Unusual presentation of synchronous double primary gallbladder and hepatic malignancies: A case report
Kun Zhang, Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Hong-Liang Liu, Department of Hepatobiliary Surgery, Qingdao Women and Children’s Hospital, Qingdao 266000, Shandong Province, China
Co-first authors: Kun Zhang and Hong-Liang Liu.
Author contributions: Zhang K was primarily responsible for the collection and organization of patient case data, drafted the initial manuscript, participated in all revisions and proofreading, and assumes responsibility for the final content of the manuscript; Liu HL proposed the clinical significance and research framework for reporting this rare case, oversaw the overall design and academic direction of the case report, performed final review and approval of the manuscript for submission, and assumes academic supervision and final accountability for the publication. Zhang K and Liu HL contributed equally to this manuscript and are co-first authors.
Informed consent statement: Informed consent was obtained from the patient for the publication of this case report and the accompanying images. All data were anonymized to ensure the protection of patient privacy.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Liang Liu, Professor, Department of Hepatobiliary Surgery, Qingdao Women and Children’s Hospital, No. 6 Tongfu Road, Qingdao 266000, Shandong Province, China. 1715069155@qq.com
Received: June 3, 2025
Revised: July 29, 2025
Accepted: September 29, 2025
Published online: October 27, 2025
Processing time: 149 Days and 1.5 Hours
Revised: July 29, 2025
Accepted: September 29, 2025
Published online: October 27, 2025
Processing time: 149 Days and 1.5 Hours
Core Tip
Core Tip: The synchronous double primary malignancies of the gallbladder and liver represent an exceedingly rare clinical entity with no established management consensus. We present a distinctive case of a 70-year-old patient who achieved no evidence of disease status following multidisciplinary intervention. This case highlights the diagnostic challenges in distinguishing synchronous primaries from metastatic disease, underscores the critical role of histopathological confirmation, and demonstrates the potential for favorable outcomes through aggressive surgical intervention. Our experience provides valuable insights for managing such complex cases.