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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2024; 16(8): 1131-1144
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1131
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1131
Tissue inhibitor of metalloproteinase-3 expression affects clinicopathological features and prognosis of aflatoxin B1-related hepatocellular carcinoma
Qiu-Ju Liang, Qin-Qin Long, Feng-Qin Tian, Qun-Ying Su, Xiao-Ying Zhu, Xi-Dai Long, Clinicopathological Diagnosis and Research Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Qiu-Ju Liang, Xi-Dai Long, Department of Tumor Pathology, Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise 533000, Guangxi Zhuang Autonomous Region, China
Co-first authors: Qiu-Ju Liang and Qin-Qin Long.
Author contributions: Liang QJ and Long QQ performed the experiments, formal analysis, and data curation, and they contributed equally to this work and should be considered as co-first authors; Tian FQ, Su QY, and Zhu XY constructed the histopathological sample library and collected the clinicopathological information and following-up data for all patients; Long XD conceptualized and designed the study, received grant support, had full access to the data, and is responsible for the integrity and accuracy of data analysis; all authors contributed to data acquisition and interpretation and reviewed and approved the final version.
Supported by the Science-Technology Planning Project of Guangxi , No. Guike-AD19245174 ; Guangxi Training Program for Medical High-level Academic Leaders , No. 6 of Guiweikejiaofa [2020]-15 ; Bose Talent Highland , No. 2020-3-2 ; Building Projects from the Key Laboratory of Molecular Pathology (Hepatobiliary Diseases) of Guangxi , No. Guiweikejiaofa [2020]-17 ; the Key Laboratory of Tumor Molecular Pathology of Guangxi Colleges and Universities , No. Guijiaokeyan [2022]-10 ; and Clinical Key Specialty Building Project (For Pathology) of Guangxi , No. Guiweiyifa [2022]-21 .
Institutional review board statement: The present study was approved by the Ethics Review Committees of Youjiang Medical University for Nationalities and carried out in accordance with the approved guidelines (No. AYJM20210708).
Informed consent statement: Informed consent from the patients was waived due to the retrospective nature of this study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xi-Dai Long, MD, PhD, Professor, Research Scientist, Clinico
Received: March 6, 2024
Revised: June 27, 2024
Accepted: July 10, 2024
Published online: August 27, 2024
Processing time: 168 Days and 21.4 Hours
Revised: June 27, 2024
Accepted: July 10, 2024
Published online: August 27, 2024
Processing time: 168 Days and 21.4 Hours
Core Tip
Core Tip: This study retrospectively analyzed tissue inhibitor of metalloproteinase-3 (TIMP3) expression and the clini