Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2024; 16(12): 1407-1416
Published online Dec 27, 2024. doi: 10.4254/wjh.v16.i12.1407
Evaluation of autoimmune phenomena in patients with nonalcoholic fatty liver disease on the basis of liver pathology
Yu-Jin Zhu, Yan Zhang, Yao Rao, Yong Jiang, Yong-Gang Liu, Jian-Zhou Li, Jia-Qi Yuan, Ying Zhao, Wen-Wen Zheng, Lin Ma, Chun-Yan Wang, Jia Li
Yu-Jin Zhu, Department of Infectious Diseases, Xi’an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi’an 710018, Shaanxi Province, China
Yan Zhang, Ying Zhao, Wen-Wen Zheng, Lin Ma, Department of Epidemiology, Tianjin Medical University, Tianjin 300070, China
Yao Rao, Chun-Yan Wang, Jia Li, Department of Gastroenterology, Clinical School of the Second People's Hospital, Tianjin 300110, China
Yong Jiang, Department of Gastroenterology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
Yong-Gang Liu, Department of Pathology, Clinical School of the Second People's Hospital, Tianjin 300110, China
Jian-Zhou Li, Jia-Qi Yuan, Department of Gastro-Enterologie, Xining Second People's Hospital, Xining 810003, Qinghai Province, China
Co-first authors: Yu-Jin Zhu and Yan Zhang.
Co-corresponding authors: Chun-Yan Wang and Jia Li.
Author contributions: Zhu YJ and Zhang Y wrote the manuscript; Rao Y, Zhao Y, Zheng WW, and Ma L contributed to data collation; Zhu YJ, Zhang Y and Li J contributed to statistical analysis; Liu YG contributed to liver pathology reading; Li JZ, Yuan JQ, Jiang Y, Wang CY and Li J contributed to manuscript revision; Wang CY and Li J contributed to research supervision; Wang CY contributed to project design.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Tianjin Second People's Hospital Institutional Review Board.
Informed consent statement: This study does not involve a substantial invasion of the subject's privacy and does not involve more than minimal risk to the subject. The waiver of informed consent will not adversely affect the rights and health of the subjects. This study does not involve personal privacy or commercial interests. Therefore, a waiver of informed consent has been applied to the Medical Ethics Committee of Tianjin Second People's Hospital.
Conflict-of-interest statement: Yu-Jin Zhu and Yan Zhang has received research funding from Tianjin Second People's Hospital.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at wangchunyan123@tmu.edu.cn. Failure to obtain consent from participants to share data.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Yan Wang, MD, Chief Physician, Department of Gastroenterology, Clinical School of the Second People's Hospital, No. 7 Sudi South Road, Nankai District, Tianjin 300110, China. wangchunyan123@tmu.edu.cn
Received: August 26, 2024
Revised: October 14, 2024
Accepted: October 29, 2024
Published online: December 27, 2024
Processing time: 98 Days and 22.1 Hours
Core Tip

Core Tip: Based on biopsy results, we divided 104 patients into three groups for a retrospective cohort study to assess the immune phenomena in patients with nonalcoholic fatty liver disease (NAFLD). Final discovery: NAFLD patients were positive for several autoantibodies. ANA is the most common antibody in NAFLD patients. Portal enlargement was the most common alteration. The incidences of limiting plate disruption and small bile duct hyperplasia are high in patients with NAFLD-related cirrhosis. Some patients had hepatocellular rosettes and were positive for antibodies. These findings indicate that autoimmune phenomena may be more pronounced in patients with NAFLD-related cirrhosis.