©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2023; 15(1): 19-40
Published online Jan 27, 2023. doi: 10.4254/wjh.v15.i1.19
Published online Jan 27, 2023. doi: 10.4254/wjh.v15.i1.19
Therapeutic interventions of acute and chronic liver disorders: A comprehensive review
Fares EM Ali, Adel G Bakr, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
Mostafa K Abd El-Aziz, Elham I Sharab, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
Author contributions: Ali FE and Bakr AG designed and critically wrote the manuscript; Abd El-Aziz MK and Sharab EI collected data and drafted the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Fares EM Ali, MSc, PhD, Lecturer, Research Scientist, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Al-Azhar Street, Assiut 71524, Egypt. faresali@azhar.edu.eg
Received: September 28, 2022
Peer-review started: September 28, 2022
First decision: October 30, 2022
Revised: November 17, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 27, 2023
Processing time: 109 Days and 15.2 Hours
Peer-review started: September 28, 2022
First decision: October 30, 2022
Revised: November 17, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 27, 2023
Processing time: 109 Days and 15.2 Hours
Core Tip
Core Tip: Acute and chronic liver diseases are worldwide problems with multifactorial pathogenesis. The exact pathological mechanism of several liver disorders is still unclear. However, many suggested mechanisms are involved, including but not limited to oxidative stress, inflammation, autophagy, and microRNA. The underlying perspective mechanisms are helpful in the discovery of new and effective therapeutic interventions for this annoying problem.