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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2020; 12(12): 1367-1371
Published online Dec 27, 2020. doi: 10.4254/wjh.v12.i12.1367
Published online Dec 27, 2020. doi: 10.4254/wjh.v12.i12.1367
Autophagy related protein 9A increase in hepatitis B virus-associated hepatocellular carcinoma and the role in apoptosis
Ingorn Kimkong, Department of Microbiology, Faculty of Science, Kasetsart University, Center for Advanced Studies in Tropical Natural Resources, National Research University – Kasetsart University, Bangkok 10900, Thailand
Areerat Kunanopparat, Department of Microbiology, Center of Excellence in Immunology and Immune Mediated Diseases, Chulalongkorn University, Bangkok 10330, Thailand
Author contributions: Kimkong I designed the research, wrote the manuscript and edited the manuscript; Kunanopparat A performed the majority of experiments and analyzed the data.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ingorn Kimkong, PhD, Associate Professor, Department of Microbiology, Faculty of Science, Kasetsart University, 50 Thanon Ngamwongwan, Lat Yao, Chatuchak, Bangkok 10900, Thailand. fsciiok@ku.ac.th
Received: July 31, 2020
Peer-review started: July 31, 2020
First decision: September 21, 2020
Revised: September 29, 2020
Accepted: October 19, 2020
Article in press: October 19, 2020
Published online: December 27, 2020
Processing time: 139 Days and 14.3 Hours
Peer-review started: July 31, 2020
First decision: September 21, 2020
Revised: September 29, 2020
Accepted: October 19, 2020
Article in press: October 19, 2020
Published online: December 27, 2020
Processing time: 139 Days and 14.3 Hours
Core Tip
Core Tip: Autophagy related protein 9A (ATG9A) protein expression was increased in tumor liver tissues compared to adjacent nontumor tissues from hepatocellular carcinoma (HCC) patients with hepatitis B virus infection. We showed that silencing ATG9A increased cell apoptosis of HepG2.2.15 and HepG2 cells. These results suggested that ATG9A protein is involved in the survival of HCC. The inhibition of ATG9A combined with other targets might be a potential drug target for HCC treatment.