Colorectal liver metastases: An update on multidisciplinary approach

doi:10.4254/wjh.v11.i2.150

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Feb 27, 2019 (publication date) through Feb 26, 2026

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Feb 27, 2019; 11(2): 150-172
Published online Feb 27, 2019. doi: 10.4254/wjh.v11.i2.150

Colorectal liver metastases: An update on multidisciplinary approach

Kenneth Siu-Ho Chok, Felix Che-Lok Chow

Felix Che-Lok Chow, Department of Surgery, Queen Mary Hospital, Hong Kong, China

Kenneth Siu-Ho Chok, Department of Surgery and State Key Laboratory for Liver Research, the University of Hong Kong, Hong Kong, China

Author contributions: Chok KSH conceptualized and supervised the study; Chow FCL did the literature review and wrote the manuscript; both authors approved the submitted version of manuscript.

Conflict-of-interest statement: None of the authors has any conflict of interest.

Corresponding author: Kenneth Siu-Ho Chok, FRCS(Ed), Associate Professor, Department of Surgery and State Key Laboratory for Liver Research, the University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China. chok6275@hku.hk

Telephone: +852-22553025 Fax: +852-28165284

Received: October 5, 2018
Peer-review started: October 6, 2018
First decision: November 15, 2018
Revised: November 24, 2018
Accepted: December 4, 2018
Article in press: December 5, 2018
Published online: February 27, 2019
Processing time: 145 Days and 4.5 Hours

Core Tip

Core tip: Surgery offers the only hope of cure in colorectal liver metastasis. It can be performed if complete metastasectomy is attainable. There is no consensus on the ideal management strategy for synchronous disease. A subset of patients presenting with unresectable disease may become eligible for resection after liver remnant augmentation or conversion therapy (chemo-therapeutics +/- biological agents). Amid increasing application of loco-regional therapies to colorectal liver metastasis, their role in the treatment paradigm remains to be defined. Refined patient selection – with greater emphasis on tumour biology – is essential to improving treatment outcome. The multidisciplinary approach helps determine the optimal treatment strategy from an expanding armamentarium of therapeutic options for each patient.