Panduro A, Roman S, Leal-Mercado L, Cardenas-Benitez JP, Mariscal-Martinez IM. Evolution of hepatology practice in Mexico and Latin America: From biochemical markers to genomic medicine. World J Hepatol 2025; 17(10): 109092 [PMID: 41179728 DOI: 10.4254/wjh.v17.i10.109092]
Corresponding Author of This Article
Arturo Panduro, MD, PhD, FAASLD, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, Fray Antonio Alcalde, Hospital #278, Col. El Retiro, Guadalajara 44280, Jalisco, Mexico. apanduro53@gmail.com
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Gastroenterology & Hepatology
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Nov 18, 2025
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World Journal of Hepatology
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1948-5182
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Panduro A, Roman S, Leal-Mercado L, Cardenas-Benitez JP, Mariscal-Martinez IM. Evolution of hepatology practice in Mexico and Latin America: From biochemical markers to genomic medicine. World J Hepatol 2025; 17(10): 109092 [PMID: 41179728 DOI: 10.4254/wjh.v17.i10.109092]
World J Hepatol. Oct 27, 2025; 17(10): 109092 Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.109092
Evolution of hepatology practice in Mexico and Latin America: From biochemical markers to genomic medicine
Arturo Panduro, Sonia Roman, Leonardo Leal-Mercado, Juan P Cardenas-Benitez, Irene M Mariscal-Martinez
Arturo Panduro, Sonia Roman, Leonardo Leal-Mercado, Juan P Cardenas-Benitez, Irene M Mariscal-Martinez, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, Fray Antonio Alcalde, Guadalajara 44280, Jalisco, Mexico
Arturo Panduro, Sonia Roman, Leonardo Leal-Mercado, Juan P Cardenas-Benitez, Irene M Mariscal-Martinez, Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico
Co-first authors: Arturo Panduro and Sonia Roman.
Author contributions: Panduro A and Roman S conceptualized and drafted the manuscript; Panduro A and Roman S contributed equally to this article, they are the co-first authors of this manuscript; Panduro A, Roman S, Leal-Mercado L, Cardenas-Benitez JP, and Mariscal-Martinez IM conducted the investigation and wrote, edited, and contributed intellectually to this manuscript; and all authors revised and approved the final manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arturo Panduro, MD, PhD, FAASLD, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, Fray Antonio Alcalde, Hospital #278, Col. El Retiro, Guadalajara 44280, Jalisco, Mexico. apanduro53@gmail.com
Received: April 30, 2025 Revised: June 4, 2025 Accepted: September 22, 2025 Published online: October 27, 2025 Processing time: 181 Days and 9.4 Hours
Abstract
Genomic medicine has evolved significantly, merging centuries of scientific progress with modern molecular biology and clinical care. It utilizes knowledge of the human genome to enhance disease prevention, diagnosis, treatment, and potential reversal. Genomic medicine in hepatology is particularly promising due to the crucial role of the liver in several metabolic processes and its association with diseases such as metabolic dysfunction-associated steatotic liver disease, type 2 diabetes mellitus, liver cirrhosis, and cardiovascular conditions. The mid-20th century witnessed a paradigm shift in medicine, marked by the emergence of molecular biology, which enabled a deeper understanding of gene expression and regulation. This connection between basic science and clinical practice has enhanced our knowledge of the role of gene-environment interactions in the onset and progression of liver diseases. In Latin America, including Mexico, with its genetically diverse and admixed populations, genomic medicine provides a foundation for personalized and culturally relevant health strategies. This review highlights the need for genomic medicine, examining its historical evolution, integration into hepatology in Mexico, and its potential applications in the prevention of chronic diseases. It emphasizes the importance of training in genomic literacy and interdisciplinary education in medical training, particularly in the field of hepatology, with a focus on genomic medicine expertise.
Core Tip: Genomic medicine in hepatology studies the gene-environment interactions that lead to the development of liver diseases. The liver expresses numerous genes involved in the physiology and pathophysiology of several comorbidities, such as diabetes, chronic liver disease, and cardiovascular disease. This work aimed to provide an overview of the study of the liver from its early days to genomic medicine, emphasizing its role in chronic diseases and its use in diagnosing and preventing them at early stages. It also highlighted the need to train healthcare professionals in genomic medicine, creating a new approach to medicine in Mexico and other Latin American countries.
