Epidermal stem cells and skin tissue engineering in hair follicle regeneration

Table 1 Owners of hair regeneration patents and patent applications matching all the descriptors found in academic literature

Assignee	No of patent applications	Percentage
Shiseido Co Ltd	5	7.69%
Aderans Research Institute Inc	5	7.69%
Hospital for Sick Children	2	3.08%
Biointegrence Inc, phoenixbio Co Ltd	2	3.08%
Follica Inc	2	3.08%
Organ technologies Inc	2	3.08%
Universitiy of Jilin	2	3.08%
University of Southern California	2	3.08%
National University of Taiwan	2	3.08%
Aderans Research Institute Inc, Bioamide Inc	1	1.54%
Agency for science, technology and research	1	1.54%
Alvi Armani Genomics Inc	1	1.54%
Anticancer Inc, Li L, Yang M	1	1.54%
Beijing Yonghe Hair Transplant Technology	1	1.54%
Biomaster KK	1	1.54%
Chen B, Gao Q, Zeng Q	1	1.54%
Chinese Academy of Science Institute of Zoology	1	1.54%
Total No of patent applications	65	100.00%
No of Entities	50

Own investigation using patent data base Thomson Innovation.

Table 2 Most cited patents from 1990 to present

Publication number	Title	Assignee	Inventor	Publication year	Count of citing patents	Ref.
WO1995001423A1	Methods of culturing and modulating the growth of hair follicular stem cells	New York State Univ, Pennsylvania Univ	Lavker RM, Sun T, Yang J	1995	29	[86]
WO2005053763A1	Hair growth method	Biointegrence Inc, Phoenixbio Co Ltd	Matsunaga M, Matsunaga MC, Shimada T, Shimada TC, Toyoshima K, Toyoshima KC, Yoshizato K	2005	17	[94]
WO2003024406A2	Nestin-expressing hair follicle stem cells	Anticancer Inc	Li L, Lingna L, Meng Y, Ri R, Yang M	2003	17	[87]
WO2005071063A1	Methods of making and using skin-derived stem cells	Hospital For Sick Children	Biernaskie J, Fernandes K, Fernandez K, Mckenzie I, Miller F, Miller FD	2005	16	[91]
WO2002060396A2	Hair follicle neogenesis by injection of follicle progenitor cells	Aderans Res Inst Inc, Bioamide Inc	Barrows TH	2002	16	[88]
US20050214344A1	Tissue engineered biomimetic hair follicle graft	Aderans Res Inst Inc	Barrows T, Barrows TH, Cochran S, Cochran SA, Marshall B	2005	15	[90]
US20070092496A1	Method of delivering cells to the skin	Aderans Res Inst Inc	Du X, Stenn K, Stenn KS, Washenik K, Washenik KJ, Zhang Y, Zheng Y	2007	10	[99]
WO2003104443A2	Hair follicle mesenchymal stem cells and use thereof	Torico Sci Innovations Inc, Trichoscience Innovations Inc	Hoffmann R, Mcelwee KJ	2003	9	[89]
US20070122387A1	Hair grafts derived from plucked hair	Aderans Res Inst Inc	Barrows TH, Cochran SA, Marshall B, Schlicher R, Su Y	2007	9	[105]
WO2007062386A2	Hair follicle graft from tissue engineered skin	Aderans Res Inst Inc	Barrows TH, Macintyre P, Washenik KJ	2007	8	[98]

Own investigation using patent data base Thomson Innovation.