Experimental study on ultrasound-targeted microbubble destruction promoting the proliferation, migration of human umbilical cord mesenchymal stem cells

Table 1 Characterization of microbubbles: Statistical table of microbubble particle size and potential distribution, mean ± SD

Characterization
Indication	MBs
Concentration (× 108/mL)	2.3 ± 0.1
Zeta potential (mV)	-13.5 ± 0
Particle size (μm)	1010 ± 178
Dispersion index	0.21 ± 0.1
Average peak value	1360.5 ± 254.5
Peak area percentage (%)	100 ± 0
Scattering angle (°)	90 ± 0

MBs: Microbubbles.

Table 2 Comparison of absorbance and activity of human umbilical cord mesenchymal stem cells under the action of microbubbles with different concentrations, mean ± SD

Microbubble concentration (particles/mL)	Absorbance	hUCMSCs proliferation rate (%)
M	1.58 ± 0.07	NA
101	1.23 ± 0.11	0.93 ± 0.26
102	1.10 ± 0.04	1.11 ± 0.27
103	1.27 ± 0.13	1.22 ± 0.33
104	1.44 ± 0.17	1.24 ± 0.26
105	1.43 ± 0.07	1.30 ± 0.37
106	1.43 ± 0.07	1.27 ± 0.25
107	1.35 ± 0.11	1.22 ± 0.32
108	0.85 ± 0.13	0.39 ± 0.09

hUCMSCs: Human umbilical cord mesenchymal stem cells; NA: Not available.