Clinical significance of mesenchymal stem cells exosomal microRNAs in predicting prognosis and inflammatory response of esophageal cancer

doi:10.4252/wjsc.119714

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jul 26, 2026; 18(7): 119714
Published online Jul 26, 2026. doi: 10.4252/wjsc.119714

Table 1 Comparison of clinical data of esophageal squamous cell carcinoma patients with different miR-375 and miR-655 expression levels, mean ± SD/n (%)

	miR-375				miR-665
	High (n = 156)	Low (n = 156)	t/χ²	P value	High (n = 156)	Low (n = 156)	t/χ²	P value
Sex			0.014	0.904			0.041	0.839
Male	105 (67.31)	104 (66.67)			101 (64.74)	108 (69.23)
Female	51 (32.69)	52 (33.33)			55 (35.26)	48 (30.77)
Age (years)	61.88 ± 8.61	60.58 ± 7.98	1.392	0.165	61.97 ± 8.74	60.49 ± 7.82	1.585	0.114
BMI (kg/m²)	22.49 ± 2.34	22.64 ± 2.15	0.567	0.571	22.42 ± 2.38	22.72 ± 2.10	1.190	0.235
Smoking			0.628	0.428			0.321	0.571
Yes	76 (48.72)	83 (53.21)			77 (49.36)	82 (51.56)
No	80 (51.28)	73 (46.79)			79 (50.64)	74 (47.44)
Alcohol			0.000	1.000			0.218	0.641
Yes	59 (37.82)	59 (37.82)			61 (39.10)	57 (35.54)
No	97 (62.18)	97 (62.18)			95 (60.90)	99 (63.46)
Family cancer history			0.502	0.478			0.126	0.723
Yes	20 (12.82)	16 (10.26)			19 (12.18)	17 (10.90)
No	136 (87.18)	140 (89.74)			137 (87.82)	139 (89.10)
Tumor site			0.580	0.748			0.874	0.646
Upper	27 (17.31)	23 (14.74)			27 (17.31)	23 (14.74)
Middle	50 (32.05)	48 (30.77)			51 (32.69)	47 (30.13)
Lower	79 (50.64)	85 (54.49)			78 (50.00)	86 (55.13)
Tumor diameter (cm)	4.81 ± 1.17	4.68 ± 1.16	0.990	0.323	4.82 ± 1.17	4.68 ± 1.16	1.097	0.274
Tumor differentiation			6.785	0.009^a			10.790	0.001^a
Moderate-high	91 (58.33)	68 (43.59)			94 (60.26)	65 (41.67)
Poor	65 (41.67)	88 (56.41)			62 (39.74)	91 (58.33)
TNM stage			7.630	0.006^a			5.197	0.023^a
Stage I-II	76 (48.72)	52 (33.33)			79 (50.64)	59 (37.82)
Stage III-IV	80 (51.28)	104 (66.67)			77 (49.36)	97 (62.18)
Lymph node metastasis			4.484	0.034^a			8.207	0.004^a
Yes	102 (65.38)	119 (76.28)			99 (63.46)	122 (78.21)
No	54 (34.62)	37 (23.72)			57 (36.54)	34 (21.79)
Preoperative CEA (ng/mL)	3.10 ± 1.45	2.99 ± 1.45	0.694	0.488	3.08 ± 1.49	3.01 ± 1.41	0.420	0.675
Preoperative CA199 (U/mL)	18.57 ± 6.90	18.20 ± 7.02	0.467	0.641	18.69 ± 6.90	18.08 ± 7.01	0.780	0.436

^aP < 0.05.

BMI: Body mass index; TNM: Tumor-node-metastases; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 19-9.

Full Size Table

Table 2 Predictive efficiency of multivariate Cox regression model for progression-free survival among different time

Time node (year)	AUC	95%CI	Sensitivity (%)	Specificity (%)	Youden index
1	0.605	0.504-0.721	67.9	51.4	0.193
3	0.651	0.588-0.716	66.0	62.5	0.285
5	0.662	0.596-0.724	60.8	68.5	0.293

CI: Confidence interval; AUC: Area under the curve.

Full Size Table

Citation: Wang JL, Niu YX, Li HX, Cui FC, Chen X. Clinical significance of mesenchymal stem cells exosomal microRNAs in predicting prognosis and inflammatory response of esophageal cancer. World J Stem Cells 2026; 18(7): 119714
URL: https://www.wjgnet.com/1948-0210/full/v18/i7/119714.htm
DOI: https://dx.doi.org/10.4252/wjsc.119714

Wang JL, Niu YX, Li HX, Cui FC, Chen X. Clinical significance of mesenchymal stem cells exosomal microRNAs in predicting prognosis and inflammatory response of esophageal cancer. World J Stem Cells 2026; 18(7): 119714 [DOI: 10.4252/wjsc.119714]

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