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World J Stem Cells. Jul 26, 2026; 18(7): 119714
Published online Jul 26, 2026. doi: 10.4252/wjsc.119714
Published online Jul 26, 2026. doi: 10.4252/wjsc.119714
Clinical significance of mesenchymal stem cells exosomal microRNAs in predicting prognosis and inflammatory response of esophageal cancer
Jin-Lin Wang, Ya-Xuan Niu, Han-Xiao Li, Fa-Cai Cui, Xiao Chen, Clinical Laboratory, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Author contributions: Wang JL conducted the majority of experiments and wrote the manuscript; Niu YX designed the study and served as a scientific advisor and guarantor; Li HX corrected the manuscript; Cui FC was involved in applying the analytical tools; Chen X participated in the collection of human material.
AI contribution statement: The authors confirm that no generative AI or AI-assisted technologies were used in the preparation of this manuscript.
Institutional review board statement: This study was approved by Henan Provincial People’s Hospital (Approval No. 2022-08), and the study followed the ethical guidelines of the Declaration of Helsinki.
Informed consent statement: Informed consent was obtained from all study participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Fa-Cai Cui, Chief Physician, Clinical Laboratory, Henan Provincial People’s Hospital, No. 7 Weiwu Road, Zhengzhou 450003, Henan Province, China. cuifacai1985@zzu.edu.cn
Received: February 27, 2026
Revised: March 19, 2026
Accepted: May 19, 2026
Published online: July 26, 2026
Processing time: 145 Days and 14.8 Hours
Revised: March 19, 2026
Accepted: May 19, 2026
Published online: July 26, 2026
Processing time: 145 Days and 14.8 Hours
Core Tip
Core Tip: Overexpression of miR-375 and miR-655 in peripheral blood mesenchymal stem cells exosomes derived from patients is associated with inflammatory factors and unfavorable prognosis in esophageal squamous cell carcinoma. Their combined evaluation provides improved prognostic stratification and may serve as a valuable adjunct for individualized clinical management. The findings aim to provide new evidence for the biological and clinical relevance of these biomarkers and offer a reference for personalized prognosis assessment and clinical decision-making in esophageal squamous cell carcinoma management.