Prospective evaluation of autologous bone marrow-derived mesenchymal stem cell injection in meniscal injury

doi:10.4252/wjsc.v18.i3.116298

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Mar 26, 2026 (publication date) through Mar 28, 2026

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Mar 26, 2026; 18(3): 116298
Published online Mar 26, 2026. doi: 10.4252/wjsc.v18.i3.116298

Table 1 Clinical outcome scores following bone marrow-derived mesenchymal stem cell therapy for meniscal pathology

Outcome measure	Baseline	3 months	6 months	12 months	P value¹
VAS pain score (0-10)	6.8 ± 1.3	4.2 ± 1.5^a	3.1 ± 1.2^a	2.1 ± 0.9^a	< 0.001
IKDC score (0-100)	42.3 ± 8.7	55.6 ± 9.3^a	64.8 ± 10.1^a	71.5 ± 10.2^a	< 0.001
Lysholm score (0-100)	58.4 ± 11.3	69.2 ± 10.8^a	78.3 ± 10.2^a	85.2 ± 9.8^a	< 0.001
KOOS pain	45.2 ± 12.1	58.3 ± 11.5^a	68.4 ± 10.8^a	75.6 ± 11.2^a	< 0.001
KOOS symptoms	48.6 ± 13.4	60.2 ± 12.7^a	69.8 ± 11.9^a	76.3 ± 12.1^a	< 0.001
KOOS ADL	52.3 ± 14.2	64.5 ± 13.1^a	73.2 ± 12.5^a	79.8 ± 11.8^a	< 0.001
KOOS Sports/Rec	35.4 ± 15.6	45.2 ± 14.8^a	56.3 ± 15.2^a	65.4 ± 14.9^a	< 0.001
KOOS QoL	38.7 ± 16.2	51.3 ± 15.4^a	62.5 ± 14.7^a	70.2 ± 13.8^a	< 0.001
ROM flexion (degrees)	118.5 ± 12.3	125.3 ± 10.2^a	131.2 ± 8.7^a	134.5 ± 7.2^a	< 0.001
ROM extension (degrees)	-3.2 ± 2.1	-1.8 ± 1.5^a	-0.8 ± 1.2^a	-0.2 ± 0.8^a	< 0.001

¹Repeated measures ANOVA.

^aSignificant difference from baseline (P < 0.001 with Bonferroni correction).

VAS: Visual Analog Scale; IKDC: International Knee Documentation Committee; KOOS: Knee Injury and Osteoarthritis Outcome Score; KOOS ADL: Knee Injury and Osteoarthritis Outcome Score activities of daily living; KOOS Sports/Rec: Knee Injury and Osteoarthritis Outcome Score sport and recreational function; KOOS QoL: Knee Injury and Osteoarthritis Outcome Score quality of life; ROM: Range of motion.

Full Size Table

Table 2 Magnetic resonance imaging T2 mapping values across meniscal regions

Meniscal region	Baseline (milliseconds)	6 months (milliseconds)	12 months (milliseconds)	Change from baseline (milliseconds)
Anterior horn	35.8 ± 3.9	33.2 ± 3.5^b	30.1 ± 3.2^a	-15.9
Body	37.4 ± 4.1	34.5 ± 3.8^b	31.3 ± 3.5^a	-16.3
Posterior horn	41.2 ± 5.1	36.8 ± 4.5^a	32.5 ± 4.2^a	-21.1
Overall meniscus	38.5 ± 4.2	34.8 ± 3.9^a	31.2 ± 3.8^a	-19.0

^aP < 0.001 vs baseline.

^bP < 0.01 vs baseline.

Full Size Table

Citation: Fu X, Song H, Wu JS, Chen X. Prospective evaluation of autologous bone marrow-derived mesenchymal stem cell injection in meniscal injury. World J Stem Cells 2026; 18(3): 116298
URL: https://www.wjgnet.com/1948-0210/full/v18/i3/116298.htm
DOI: https://dx.doi.org/10.4252/wjsc.v18.i3.116298