Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse

doi:10.4252/wjsc.v16.i6.708

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Jun 26, 2024 (publication date) through Oct 22, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jun 26, 2024; 16(6): 708-727
Published online Jun 26, 2024. doi: 10.4252/wjsc.v16.i6.708

Table 1 Clinical data of patients with and without pelvic organ prolapse

Parameters	Non-POP	POP	P value
Age (yr), mean ± SD	52.5 ± 7.184	57.9 ± 11.03	NS¹
BMI (kg/m²), mean ± SD	24.57 ± 3.655	23.3 ± 2.943	NS¹
Parity (n), mean ± SD	1.8 ± 0.4216	1.2 ± 0.4206	NS²
Menopause, n (%)	70%	50%	NS³
POP stage, median (range)	0	3 (3-4)	< 0.0001

¹Independent sample t test.

²Welch’s t test.

³Mann-Whitney test.

NS: Not significant; BMI: Body mass index; POP: Pelvic organ prolapse.

Full Size Table

Table 2 The primers sequences utilized in this study

Gene	Primer sequences
Col 1A1 FW	GTGCGATGACGTGATCTGTGA
Col 1A1 RV	CGGTGGTTTCTTGGTCGGT
Col 1A2 FW	TTGAAGGAGGATGTTCCCATCT
Col 1A2 RV	ACAGACACATATTTGGCATGGTT
Col 3A1 FW	TTGAAGGAGGATGTTCCCATCT
Col 3A1 RV	ACAGACACATATTTGGCATGGTT
MMP1 FW	CTCTGGAGTAATGTCACACCTCT
MMP1 RV	TGTTGGTCCACCTTTCATCTTC
TIMP1 FW	AGAGTGTCTGCGGATACTTCC
TIMP1 RV	CCAACAGTGTAGGTCTTGGTG
Elastin FW	GCAGGAGTTAAGCCCAAGG
Elastin RV	TGTAGGGCAGTCCATAGCCA
LOX FW	CGGCGGAGGAAAACTGTCT
LOX RV	TCGGCTGGGTAAGAAATCTGA
GAPDH FW	TGACATCAAGAAGGTGGTGAAGCAG
GAPDH RV	GTGTCGCTGTTGAAGTCAGAGGAG

MMP1: Matrix metalloproteinase 1; TIMP1: Tissue inhibitor of matrix metalloprotease 1; LOX: Lysyl oxidase.

Full Size Table

Citation: Xu LM, Yu XX, Zhang N, Chen YS. Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse. World J Stem Cells 2024; 16(6): 708-727
URL: https://www.wjgnet.com/1948-0210/full/v16/i6/708.htm
DOI: https://dx.doi.org/10.4252/wjsc.v16.i6.708