Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury: A comparative analysis with mesenchymal stem cells

doi:10.4252/wjsc.v16.i5.525

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. May 26, 2024; 16(5): 525-537
Published online May 26, 2024. doi: 10.4252/wjsc.v16.i5.525

Table 1 Effects of urine-derived stem cells and bone marrow mesenchymal stem cells on renal morphology and tubular apoptosis

	AKI	AKI + USCs	AKI + BMSCs	Control
Cast (n/hpf)	6.12 ± 3.12	1.24 ± 1.12^a	1.53 ± 0.32^b	0
Necrosis (n/hpf)	4.35 ± 3.19	1.65 ± 1.17^a	0.85 ± 0.27^b	0
TUNEL-positive cells (n/hpf)	19.8 ± 13.2	4.02 ± 1.21^a	8.14 ± 3.5^b	0

^aP < 0.05 for urine-derived stem cell injection versus untreated acute kidney injury.

^bP < 0.05 for bone marrow mesenchymal stem cell injection versus untreated acute kidney injury.

Comparison of urine-derived stem cell or bone marrow mesenchymal stem cell injection on tubular morphology and apoptosis on day 5 after acute kidney injury induction. Numbers in the table represent the mean ± SD of tubular casts and necrotic tubules and of apoptotic cells detected by terminal deoxynucleotidyl transferase dUTP nick-end labeling, observed under high power (magnification, 400 ×). AKI: Acute kidney injury; USC: Urine-derived stem cell; BMSC: Bone marrow mesenchymal stem cell; TUNEL: Terminal deoxynucleotidyl transferase dUTP nick-end labeling; hpf: High-powered field.

Citation: Li F, Zhao B, Zhang L, Chen GQ, Zhu L, Feng XL, Gong MJ, Hu CC, Zhang YY, Li M, Liu YQ. Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury: A comparative analysis with mesenchymal stem cells. World J Stem Cells 2024; 16(5): 525-537
URL: https://www.wjgnet.com/1948-0210/full/v16/i5/525.htm
DOI: https://dx.doi.org/10.4252/wjsc.v16.i5.525