Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research

Table 1 Main genes associated with inherited cardiomyopathies

Condition	Genotype	Ref.
HCM1	MYBPC3, MYH7, TNNT2, TNNI3, TPM1, ACTC1, MYL2, MYL3	[13]
DCM	TTN, LMNA, MYH7, TNNT2, BAG3, RBM20, TNNC1, TNNI3, TPM1, SCN5A, PLN	[14,15]
LVNC	Overlap with HCM and DCM	[14,15]
ACM	DES, DSC2, DSG2, DSP, JUP, LMNA, PKP2, PLN, RYR2, SCN5A, TMEM43, TTN	[14,15]
RCM	TTR, TNNI3, DES. Overlap with HCM and DCM	[14,15]

¹Only genes having definitive evidence for hypertrophic cardiomyopathy have been depicted. ACM: Arrhythmogenic cardiomyopathy; DCM: Dilated cardiomyopathy; HCM: Hypertrophic cardiomyopathy; LVNC: Left ventricular noncompaction; RCM: Restrictive cardiomyopathy.

Table 2 Main genes associated with inherited channelopathies

Condition	Genotype	Ref.
LQTS1	KCNQ1	[16]
LQTS2	KCNH2	[16]
LQTS3	SCN5A	[16]
LQTS4	ANK2	[17]
LQTS5	KCNE1	[17]
LQTS6	KCNE2	[17]
LQTS7	KCNJ2	[17]
LQTS8	CACNA1C	[17]
LQTS9	CAV3	[17]
LQTS10	SCN4B	[17]
LQTS11	AKAP9	[17]
LQTS12	SNTA1	[17]
LQTS13	KCNJ5	[17]
LQTS14	CALM1	[17]
LQTS15	CALM2	[17]
JLN1	KCNQ1	[17]
JLN2	KCNE1	[17]
CPVT1	RYR2	[16]
CPVT2	CASQ2	[16]
SQTS	KCNH2, KCNQ1, KCNJ2	[16]
BrS	SCN5A	[18]

BrS: Brugada syndrome; CPVT: Catecholaminergic polymorphic ventricular tachycardia; LQTS: Long QT syndrome; SQTS: Short QT syndrome.