Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research

Core Tip

Core Tip: Induced pluripotent stem cell (iPSC) technology holds a great potential for medical research. Patient-specific iPSC-derived cardiomyocytes offer a unique framework for various applications, such as cardiotoxicity screening, drug discovery, disease modeling, and cell therapy. In the particular case of inherited cardiomyopathies and channelopathies, iPSC-based models have prompted study of disease mechanisms in an individual-/allele-specific manner, as well as the customization of therapeutic regimens. Herein, we present and critically discuss the current knowledge and key experimental approaches that support patient-specific iPSCs as robust “disease-in-a-dish” models for genetic cardiomyopathies and channelopathies after 15 years of research.