Human hair follicle-derived mesenchymal stem cells: Isolation, expansion, and differentiation

Figure 1 Schematic of the human hair follicle. An intact hair follicle usually includes the inner root sheath, outer root sheath, and connective tissue sheath (dermal sheath). The human hair follicle mesenchymal stem cells lie within the dermal papilla or dermal sheath (connective tissue sheath) of the hair follicle. Citation: Kiani MT, Higgins CA, Almquist BD. The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine. ACS Biomater Sci Eng 2018; 4: 1193-1207. Copyright^© The Authors 2018. Published by American Chemical Society.

Figure 2 Isolation of human hair follicle mesenchymal stem cells. Human hair follicle mesenchymal stem cells migrating out of the dermal sheath or papilla show the morphological appearance of fibroblast-like cells. Bar: 200 μm. Citation: Jiang Y, Liu F, Zou F, Zhang Y, Wang B, Zhang Y, Lian A, Han X, Liu Z, Liu X, Jin M, Wang D, Li G, Liu J. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis. Stem Cell Res Ther 2019; 10: 268. Copyright^© The Authors 2019. Published by Springer Nature.