©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2016; 8(6): 216-222
Published online Jun 26, 2016. doi: 10.4252/wjsc.v8.i6.216
Published online Jun 26, 2016. doi: 10.4252/wjsc.v8.i6.216
Aneuploidy in stem cells
Jorge Garcia-Martinez, Bjorn Bakker, Klaske M Schukken, Judith E Simon, Floris Foijer, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV Groningen, The Netherlands
Author contributions: Garcia-Martinez J and Bakker B contributed equally; all authors contributed to this paper.
Supported by The Pediatric Oncology Foundation Groningen (SKOG; http://www.kinderoncologiegroningen.nl); European Union (Marie Curie Innovative Training Network PloidyNet, http://aneuploidy.nl); and Dutch Cancer Society (http://www.kwf.nl grant# 2012-RUG-5549) for funding.
Conflict-of-interest statement: Authors declare that they have no conflict of interest.
Correspondence to: Floris Foijer, PhD, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, NL-9713 AV Groningen, The Netherlands. f.foijer@umcg.nl
Telephone: +31-50-3617300 Fax: +31-50-3617310
Received: November 17, 2015
Peer-review started: November 23, 2015
First decision: January 18, 2016
Revised: February 18, 2016
Accepted: March 17, 2016
Article in press: March 18, 2016
Published online: June 26, 2016
Processing time: 217 Days and 7 Hours
Peer-review started: November 23, 2015
First decision: January 18, 2016
Revised: February 18, 2016
Accepted: March 17, 2016
Article in press: March 18, 2016
Published online: June 26, 2016
Processing time: 217 Days and 7 Hours
Core Tip
Core tip: Stem cells hold great therapeutic promise for regenerative medicine, especially with new protocols that can create induced pluripotent stem cells from terminally differentiated cells. However, somatic cells and stem cells cope differently with genomic instability. Therefore, it will be of the utmost importance to assess genomic integrity when preparing stem cell cultures for future therapy.