Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2016; 8(5): 202-215
Published online May 26, 2016. doi: 10.4252/wjsc.v8.i5.202
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse
Stuart J Emmerson, Caroline E Gargett
Stuart J Emmerson, Caroline E Gargett, the Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia
Stuart J Emmerson, Caroline E Gargett, Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria 3168, Australia
Author contributions: Emmerson SJ contributed to the acquisition of data, analysis and interpretation of data, drafting, writing the article and approved the final version; Gargett CE contributed to the conception and design of the study, critical revision related to the important intellectual content, editing and approval of the final version.
Conflict-of-interest statement: The authors have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Caroline E Gargett, PhD, Associate Professor, the Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Melbourne, Victoria 3168, Australia. caroline.gargett@hudson.org.au
Telephone: +61-3-85722795 Fax: +61-3-95947439
Received: October 30, 2015
Peer-review started: November 4, 2015
First decision: November 30, 2015
Revised: December 23, 2015
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: May 26, 2016
Processing time: 200 Days and 16.5 Hours
Core Tip

Core tip: Pelvic organ prolapse is the herniation of pelvic organs into the vaginal cavity and affects approximately 25% of all women. Traditional mesh-augmented surgical treatments cause complications such as pain and mesh erosion. A tissue engineering approach using endometrial mesenchymal stem cells seeded on new composite mesh show promise in animal models through their modulation of the chronic inflammatory response and promotion of physiological and biomechanically compliant neotissue.