Migration of bone marrow progenitor cells in the adult brain of rats and rabbits

doi:10.4252/wjsc.v8.i4.136

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Apr 26, 2016 (publication date) through Mar 4, 2026

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2016; 8(4): 136-157
Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.136

Migration of bone marrow progenitor cells in the adult brain of rats and rabbits

Donnahue Dennie, Jean-Pierre Louboutin, David S Strayer

Donnahue Dennie, Jean-Pierre Louboutin, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica

David S Strayer, Department of Cell Biology, Anatomy and Pathology, Thomas Jefferson University, Philadelphia, PA 19107, United States

Author contributions: Dennie D and Louboutin JP contributed equally to writing the paper; Strayer DS supervised the work.

Conflict-of-interest statement: There is no conflict of interest.

Correspondence to: Jean-Pierre Louboutin, MD, PhD, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, West Road, Kingston 7, Jamaica. jplouboutin@hotmail.com

Telephone: +876-3680554

Received: June 2, 2015
Peer-review started: June 7, 2015
First decision: July 6, 2015
Revised: October 19, 2015
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: April 26, 2016
Processing time: 316 Days and 9.7 Hours

Core Tip

Core tip: It was previously thought that the development of new neurons did not take place in the adult brain of higher vertebrates. There has been substantial progress in understanding neurogenesis in the adult brain during the last decade, showing that neural progenitor cells can induce neurogenesis, mainly in three areas: Subventricular zone, subgranular zone of the hippocampal dentate gyrus, and olfactory bulb. More recently, it has been shown that bone marrow progenitor cells can participate in neurogenesis in the adult brain. In this review, we discuss the mechanisms of the migration, differentiation, and maturation of bone marrow progenitor cells in the adult brain. We also consider the increase of adult neurogenesis following experimental seizures, provided that neuroinflammation is decreased by reducing the expression of chemokines, and consequently the related migration of inflammatory cells into the brain parenchyma.