Human pluripotent stem cells: Towards therapeutic development for the treatment of lifestyle diseases

doi:10.4252/wjsc.v8.i2.56

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Feb 26, 2016 (publication date) through Mar 3, 2026

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World Journal of Stem Cells

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World J Stem Cells. Feb 26, 2016; 8(2): 56-61
Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.56

Human pluripotent stem cells: Towards therapeutic development for the treatment of lifestyle diseases

Miwako Nishio, Masako Nakahara, Akira Yuo, Kumiko Saeki

Miwako Nishio, Masako Nakahara, Akira Yuo, Kumiko Saeki, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan

Kumiko Saeki, PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan

Author contributions: Nishio M, Nakahara M, Yuo A and Saeki K together wrote the manuscript after intensive discussion.

Conflict-of-interest statement: We have no conflict of Interests to be declared.

Correspondence to: Kumiko Saeki, MD, PhD, Director, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. saeki@ri.ncgm.go.jp

Telephone: +81-3-32027181 Fax: +81-3-32071038

Received: August 17, 2015
Peer-review started: August 21, 2015
First decision: September 30, 2015
Revised: December 17, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: February 26, 2016
Processing time: 190 Days and 2.2 Hours

Core Tip

Core tip: Clinical application of human embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) is currently limited to remediless diseases due to risk of tumorigenesis. However, application of these cells to therapeutic purposes and drug discovery for lifestyle diseases is promising. Because a short-term presence of human ESC/iPSC-derived vascular endothelial cells reportedly exerts long-term therapeutic effects on injured stenotic arteries, immunologically rejections can nullify risk of tumorigenesis without deteriorating therapeutic effects. Another utility is to produce high-scarcity-valued cells such as brown adipocytes, which are unobtainable from living bodies and commercially available sources, as a new tool for drug discovery for lifestyle diseases.