©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2016; 8(2): 47-55
Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.47
Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.47
Use of platelet lysate for bone regeneration - are we ready for clinical translation?
Ala Altaie, Heather Owston, Elena Jones, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, St. James’s University Hospital, Leeds LS9 7TF, United Kingdom
Author contributions: Altaie A, Owston H and Jones E prepared the manuscript; Altaie A contributed to data generation and analysis.
Supported by Leeds Musculoskeletal Biomedical Research Unit (Elena Jones), EPSRC (Heather Owston).
Conflict-of-interest statement: No potential conflicts of interest.
Correspondence to: Elena Jones, PhD, Associate Professor in Stem Cell Biology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, St. James’s University Hospital, Beckett Street, Leeds LS9 7TF, United Kingdom. msjej@leeds.ac.uk
Telephone: +44-113-2065647 Fax: +44-113-343850
Received: August 28, 2015
Peer-review started: September 4, 2015
First decision: November 27, 2015
Revised: January 14, 2016
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: February 26, 2016
Processing time: 178 Days and 20.5 Hours
Peer-review started: September 4, 2015
First decision: November 27, 2015
Revised: January 14, 2016
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: February 26, 2016
Processing time: 178 Days and 20.5 Hours
Core Tip
Core tip: Human platelet lysate (PL) offers an exciting opportunity for expanding mesenchymal stem cells (MSCs), as well as for use in bone regeneration as a scaffold coating. In this review, we describe the state-of-the-art research in the area of bone regeneration utilising PL and MSCs and emphasise the need for standardisation of PL preparation and its quality control in order to progress further in this exciting area of research. Different PL formulations could be tailor-made for specific scaffolds and bone repair indications, both in autologous and allogenic settings. More pre-clinical and clinical work is needed to progress this research into clinical translation.