©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2015; 7(3): 618-629
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.618
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.618
Stem cell therapy in intracerebral hemorrhage rat model
Marcos F Cordeiro, Ana P Horn, Programa de Pós-graduação em Ciências Fisiológicas-Fisiologia Animal Comparada, Universidade Federal do Rio Grande, Rio Grande RS 96210-900, Brazil
Marcos F Cordeiro, Ana P Horn, Laboratório de Histologia, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande RS 96210-900, Brazil
Marcos F Cordeiro, Ana P Horn, Laboratório de Neurociências, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande RS 96210-900, Brazil
Author contributions: Cordeiro MF and Horn AP contributed to this paper.
Conflict-of-interest: The authors have no conflicts of interest to declare.
Correspondence to: Marcos F Cordeiro, BSc, Laboratório de Histologia, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Av Itália, Km 8, Rio Grande RS 96210-900, Brazil. cordeiromf@yandex.com
Telephone: +55-53-32935182 Fax: +55-53-32936848
Received: July 29, 2014
Peer-review started: July 29, 2014
First decision: November 18, 2014
Revised: December 5, 2014
Accepted: December 18, 2014
Article in press: December 19, 2014
Published online: April 26, 2015
Processing time: 268 Days and 6.9 Hours
Peer-review started: July 29, 2014
First decision: November 18, 2014
Revised: December 5, 2014
Accepted: December 18, 2014
Article in press: December 19, 2014
Published online: April 26, 2015
Processing time: 268 Days and 6.9 Hours
Core Tip
Core tip: In this review, we first summarize intracerebral hemorrhage (ICH) epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts.