©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2015; 7(3): 568-582
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.568
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.568
Vibration stimuli and the differentiation of musculoskeletal progenitor cells: Review of results in vitro and in vivo
Jennifer Helen Edwards, Gwendolen Clair Reilly, Kroto Research Institute and INSIGNEO Institute for in silico Medicine, Department of Materials Science and Engineering, University of Sheffield, S1 3JD Sheffield, United Kingdom
Jennifer Helen Edwards, Institute of Medical and Biological Engineering, Faculty of Biological Sciences, University of Leeds, LS2 9JT Leeds, United Kingdom
Author contributions: Edwards JH researched the articles and wrote the manuscript; Reilly GC advised on structure and edited the manuscript.
Supported by Engineering and Physical Sciences Research Council.
Conflict-of-interest: No potential conflicts of interest relevant to this article were reported.
Correspondence to: Jennifer Helen Edwards, PhD, Institute of Medical and Biological Engineering, Faculty of Biological Sciences, University of Leeds, LS2 9JT Leeds, United Kingdom. j.h.edwards@leeds.ac.uk
Telephone: +44-113-3435617
Received: August 1, 2014
Peer-review started: August 2, 2014
First decision: October 14, 2014
Revised: November 25, 2014
Accepted: December 16, 2014
Article in press: December 17, 2014
Published online: April 26, 2015
Processing time: 265 Days and 8.4 Hours
Peer-review started: August 2, 2014
First decision: October 14, 2014
Revised: November 25, 2014
Accepted: December 16, 2014
Article in press: December 17, 2014
Published online: April 26, 2015
Processing time: 265 Days and 8.4 Hours
Core Tip
Core tip: Low magnitude, high frequency vibrations are attracting growing interest as a non-invasive therapy for a variety of different disorders. The number of studies aimed at elucidating the effects of vibration both in vivo and in vitro is increasing rapidly. This review aims to provide an introductory overview of the in vivo data for a broad range of human applications and animal models. In vitro work is covered in more detail, focusing in particular on studies concerning the effects of vibration on cells derived from the musculoskeletal system.