©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2015; 7(3): 547-555
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.547
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.547
New insights into pancreatic cancer stem cells
Chinthalapally V Rao, Altaf Mohammed, Center for Cancer Prevention and Drug Development, Department of Medicine, Hematology-Oncology Section, PC Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
Author contributions: Mohammed A prepared the original draft; Rao CV revised and finalized the manuscript.
Supported by In part by Kerley Cade Endowed Chair (Chinthalapally V Rao), University of Oklahoma Health Sciences Center; and in part support from the National Cancer Institute, No. 5R03CA181584-02 (Altaf Mohammed).
Conflict-of-interest: The authors declare no potential conflict of interest.
Correspondence to: Altaf Mohammed, PhD, Center for Cancer Prevention and Drug Development, Department of Medicine, Hematology-Oncology Section, PC Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC II, Room 1209B, Oklahoma City, OK 73104, United States. amohamme@ouhsc.edu
Telephone: +1-405-2713224 Fax: +1-405-2713225
Received: August 11, 2014
Peer-review started: August 13, 2014
First decision: November 3, 2014
Revised: December 2, 2014
Accepted: December 16, 2014
Article in press: December 17, 2014
Published online: April 26, 2015
Processing time: 254 Days and 23.5 Hours
Peer-review started: August 13, 2014
First decision: November 3, 2014
Revised: December 2, 2014
Accepted: December 16, 2014
Article in press: December 17, 2014
Published online: April 26, 2015
Processing time: 254 Days and 23.5 Hours
Core Tip
Core tip: Despite aggressive treatment modalities, pancreatic cancer represents most lethal malignancy with uniform lethality. The pancreatic cancer stem cells (CSCs) have been found to be resistant to chemotherapy and radiation therapy. This review summarizes the important role of CSCs in pancreatic cancer tumor progression with emphasis on DclK1 and Lgr5 CSCs, molecular signaling altered by CSCs and the important role of pancreatic CSCs in prevention and treatment of pancreatic cancer.