Dedifferentiated fat cells: A cell source for regenerative medicine

doi:10.4252/wjsc.v7.i10.1202

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Nov 26, 2015 (publication date) through Mar 5, 2026

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2015; 7(10): 1202-1214
Published online Nov 26, 2015. doi: 10.4252/wjsc.v7.i10.1202

Dedifferentiated fat cells: A cell source for regenerative medicine

Medet Jumabay, Kristina I Boström

Medet Jumabay, Kristina I Boström, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, United States

Kristina I Boström, the Molecular Biology Institute at UCLA, Los Angeles, CA 90095-1570, United States

Author contributions: All the authors contributed to this paper.

Supported by In part by the American Heart Association (Medet Jumabay); NIH grants P01 HL30568, R01 HL81397, and R01 HL112839 (Kristina I Boström).

Conflict-of-interest statement: The authors declare that there is no conflict of interest.

Correspondence to: Medet Jumabay, MD, PhD, Division of Cardiology, David Geffen School of Medicine at UCLA, Box 951679, Los Angeles, CA 90095-1679, United States. mjumabay@mednet.ucla.edu

Telephone: +1-310-2674951 Fax: +1-310-2068553

Received: January 22, 2015
Peer-review started: January 22, 2015
First decision: March 6, 2015
Revised: September 22, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: November 26, 2015
Processing time: 309 Days and 9.6 Hours

Core Tip

Core tip: Multipotent dedifferentiated fat (DFAT) cells provide evidence of plasticity in adipocytes. The newly established DFAT cells exhibit vigorous proliferation and multipotent abilities with advantages over other adult stem cells. Modified culture methods reduce the risk of contamination by cells from the stromal vascular fraction to a minimum. In in vitro and/or in vivo experiments have revealed adipogenic, osteogenic, chondrogenic, myogenic, angiogenic and neourogenic potentials in DFAT cells. Moreover, the DFAT cells express embryonic stem cell markers and are similar to induced pluripotent stem cells in certain physiological aspects. Based on the abundance, ease of preparation, homogeneity, and multi-lineage potential, the DFAT cells are uniquely suited for regenerative medicine.