Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2014; 6(3): 312-321
Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.312
Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.312
Adipose-derived stem cells: Implications in tissue regeneration
Wakako Tsuji, J Peter Rubin, Kacey G Marra, Adipose Stem Cell Center, Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States
J Peter Rubin, Kacey G Marra, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States
J Peter Rubin, Kacey G Marra, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, United States
Author contributions: Tsuji W and Marra KG wrote the manuscript; Rubin JP and Marra KG supervised the paper.
Correspondence to: Kacey G Marra, Associate Professor, Adipose Stem Cell Center, Department of Plastic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, United States. marrak@upmc.edu
Telephone: +1-412-3838924 Fax: +1-412-3614643
Received: February 23, 2014
Revised: April 16, 2014
Accepted: June 10, 2014
Published online: July 26, 2014
Processing time: 146 Days and 5 Hours
Revised: April 16, 2014
Accepted: June 10, 2014
Published online: July 26, 2014
Processing time: 146 Days and 5 Hours
Core Tip
Core tip: This review article provides an overview on adipose-derived stem cells (ASCs) for implications in tissue regeneration. ASCs are obtained in high yields from abundant adipose tissue in the body and have multi-lineage differentiation ability. This article focuses on ASC characterization, growth factor secretion from ASCs, differentiation ability in vitro and in vivo, and the potential clinical applications.