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World J Stem Cells. Apr 26, 2014; 6(2): 144-152
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.144
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.144
Adipose mesenchymal stem cells in the field of bone tissue engineering
Cecilia Romagnoli, Maria Luisa Brandi, Metabolic Bone Diseases Branch, Department of Surgery and Translational Medicine, University of Florence, Florence 50139, Italy
Author contributions: Romagnoli C conceived and designed the paper, reviewed the literature and wrote the paper; Brandi ML revised and approved the final version of the paper.
Supported by The Regione Toscana-POR CRO FSE 2007-2013 and I.F.B. STRODER s.r.l.
Correspondence to: Maria Luisa Brandi, MD, PhD, Metabolic Bone Diseases Branch, Department of Surgery and Translational Medicine, University of Florence, Largo Palagi 1, Florence 50139, Italy. marialuisa.brandi@unifi.it
Telephone: +39-55-7946304 Fax: +39-55-7946303
Received: November 19, 2013
Revised: December 19, 2013
Accepted: March 3, 2014
Published online: April 26, 2014
Processing time: 184 Days and 20 Hours
Revised: December 19, 2013
Accepted: March 3, 2014
Published online: April 26, 2014
Processing time: 184 Days and 20 Hours
Core Tip
Core tip: The complex and dynamic process of bone tissue engineering is a challenging field in regenerative medicine. Current research is focused on the optimization and facilitation of bone regeneration by combining growth factors and mesenchymal stem cells with the many types of materials that have been studied as scaffolds. This review presents an overview of ideal scaffold properties and discusses the application of adipose-derived stem cells in bone tissue engineering and translational medicine.