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World J Stem Cells. Aug 26, 2026; 18(8): 120369
Published online Aug 26, 2026. doi: 10.4252/wjsc.120369
Published online Aug 26, 2026. doi: 10.4252/wjsc.120369
Letter to the Editor: Exosomal circular RNAs from peripheral blood-derived mesenchymal stem cells as diagnostic and subtyping biomarkers in acute mesenteric ischemia
Ramya Lakshmi Rajendran, BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn, Cardiovascular Research Institute, Kyungpook National University, Daegu 41944, South Korea
Atharva A Mahajan, Department of Biotechnology, University of Mysore, Mysore 570005, Karnataka, India
Kandasamy Nagarajan ArulJothi, Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India
Sree Naga Sowndary Rajendran, Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Byeong-Cheol Ahn, Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu 41944, South Korea
Co-first authors: Ramya Lakshmi Rajendran and Atharva A Mahajan.
Co-corresponding authors: Prakash Gangadaran and Byeong-Cheol Ahn.
Author contributions: Rajendran RL and Mahajan AA contributed equally to this work and are regarded as co-first authors. Rajendran RL, Mahajan AA, ArulJothi KN, Rajendran SNS, Gangadaran P, and Ahn BC designed the overall concept and outline of the manuscript, contributed to the discussion and design of the manuscript, manuscript writing and editing, illustrations, and the literature review. Gangadaran P and Ahn BC served as co-corresponding authors and contributed equally to the supervision, critical revision, and final approval of the manuscript.
AI contribution statement: An AI-based tools (Wordvice AI or ChatGPT by OpenAI, GPT-5.2, accessed April 2026) was used under author supervision in a limited manner to improve English expression, clarify structure, and adjust word count. The authors reviewed and edited the content independently and take full responsibility for the final manuscript.
Supported by Basic Science Research Program Through the National Research Foundation of Korea funded by the Ministry of Education, No. NRF-2022R1I1A1A01068652.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Corresponding author: Byeong-Cheol Ahn, MD, PhD, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu 41944, South Korea. abc2000@knu.ac.kr
Received: February 25, 2026
Revised: March 30, 2026
Accepted: May 6, 2026
Published online: August 26, 2026
Processing time: 176 Days and 21.1 Hours
Revised: March 30, 2026
Accepted: May 6, 2026
Published online: August 26, 2026
Processing time: 176 Days and 21.1 Hours
Core Tip
Core Tip: Peripheral blood-derived mesenchymal stem cell exosomal circ-Eya3 and circEZH2_005 represent a promising step toward a ‘liquid biopsy’ approach for acute mesenteric ischemia. Beyond simple diagnosis, their differential expression patterns showed a statistically significant variance between arterial and venous etiologies in this cohort, suggesting a potential role in etiologic differentiation that may help signal the critical transition from early reversible ischemia to ad