Enhancing mesenchymal stem cell function with epiregulin in tissue engineering: From tissue regeneration to gut microbiota modulation

doi:10.4252/wjsc.119865

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Opinion Review

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jul 26, 2026; 18(7): 119865
Published online Jul 26, 2026. doi: 10.4252/wjsc.119865

Enhancing mesenchymal stem cell function with epiregulin in tissue engineering: From tissue regeneration to gut microbiota modulation

Andrei A Dudun, Garina A Bonartseva, Anton P Bonartsev

Andrei A Dudun, Garina A Bonartseva, Anton P Bonartsev, A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia

Anton P Bonartsev, Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow 119234, Russia

Author contributions: Bonartsev AP designed the study; Dudun AA, Bonartseva GA, and Bonartsev AP performed the research and reviewed and edited the manuscript; Dudun AA and Bonartsev AP wrote the original draft; all authors have read and approved the final manuscript.

AI contribution statement: AI was not used in the preparation, writing, editing, or revision of this manuscript.

Supported by the Russian Science Foundation (No. 25-26-00587).

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Anton P Bonartsev, PhD, Associate Professor, Faculty of Biology, M.V. Lomonosov Moscow State University, Leninskie Gory 1, Bld 12, Moscow 119234, Russia. ant_bonar@mail.ru

Received: February 12, 2026
Revised: April 23, 2026
Accepted: June 3, 2026
Published online: July 26, 2026
Processing time: 166 Days and 12.3 Hours

Core Tip

Core Tip: Epiregulin enhances the migration, chemotaxis, and osteogenesis of mesenchymal stem cells under inflammatory conditions and can be used to treat various diseases associated with inflammation. In this opinion review, we discuss the prospects of using epiregulin to enhance the function of mesenchymal stem cells in tissue engineering applications, including bone, skin, liver, and intestinal regeneration, as well as gut microbiota modulation.