Liang ZY, Hu HS. Letter to the Editor: Extracellular vesicles in diabetic bladder dysfunction - a promising cell-free therapeutic avenue from amniotic fluid stem cells. World J Stem Cells 2026; 18(7): 117525 [DOI: 10.4252/wjsc.117525]
Corresponding Author of This Article
Zhuo-Yin Liang, MD, Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, No. 151 Yanjiang West Road, Guangzhou 510120, Guangdong Province, China. emeyou@163.com
Research Domain of This Article
Andrology
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letter
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Liang ZY, Hu HS. Letter to the Editor: Extracellular vesicles in diabetic bladder dysfunction - a promising cell-free therapeutic avenue from amniotic fluid stem cells. World J Stem Cells 2026; 18(7): 117525 [DOI: 10.4252/wjsc.117525]
World J Stem Cells. Jul 26, 2026; 18(7): 117525 Published online Jul 26, 2026. doi: 10.4252/wjsc.117525
Letter to the Editor: Extracellular vesicles in diabetic bladder dysfunction - a promising cell-free therapeutic avenue from amniotic fluid stem cells
Zhuo-Yin Liang, Hai-Sheng Hu
Zhuo-Yin Liang, Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China
Hai-Sheng Hu, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China
Co-first authors: Zhuo-Yin Liang and Hai-Sheng Hu.
Author contributions: Liang ZY and Hu HS contributed equally to this manuscript and are co-first authors. Hu HS designed the overall concept and outline of the manuscript; Liang ZY contributed to the writing and editing of the manuscript and illustrations of the literature. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Zhuo-Yin Liang, MD, Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, No. 151 Yanjiang West Road, Guangzhou 510120, Guangdong Province, China. emeyou@163.com
Received: December 10, 2025 Revised: January 16, 2026 Accepted: February 12, 2026 Published online: July 26, 2026 Processing time: 227 Days and 4.1 Hours
Core Tip
Core Tip: This letter examines the transformative potential of stem cell-derived extracellular vesicles as a novel cell-free regenerative strategy for diabetic bladder dysfunction. This underscores their unique capacity to simultaneously modulate urodynamic function, systemic metabolism, and local inflammatory-fibrotic pathways, thereby addressing the multifactorial pathogenesis of the condition. Representing a shift from symptomatic management to disease modification, extracellular vesicles offer a favorable safety profile and enhanced translational feasibility compared with whole-cell therapies. This discussion further outlines the critical steps for clinical integration, including cargo optimization, manufacturing standardization, and combination with postoperative rehabilitation.
