Mesenchymal stem cell secretome and exosomes as potential advanced therapy medicinal products for treating a failing heart

doi:10.4252/wjsc.113871

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jul 26, 2026; 18(7): 113871
Published online Jul 26, 2026. doi: 10.4252/wjsc.113871

Mesenchymal stem cell secretome and exosomes as potential advanced therapy medicinal products for treating a failing heart

Syed Mohammad Habib, Mohammad Fateh Martini, Yacoub Nail Hamdan Abu-Hamdan, Omran Mohammed Marwan Shrebaty, Khawaja Husnain Haider

Syed Mohammad Habib, Mohammad Fateh Martini, Yacoub Nail Hamdan Abu-Hamdan, Omran Mohammed Marwan Shrebaty, Khawaja Husnain Haider, Department of Basic Sciences, Sulaiman Alrajhi Medical School, Al Bukairiyah 51941, Saudi Arabia

Author contributions: Habib SM and Haider KH conceptualized and presented the idea; Habib SM, Martini MF, Abu-Hamdan YNH, Shrebaty OMM, and Haider KH drafted the manuscript and tables; Habib SM and Haider KH took the lead; Habib SM prepared the illustrations and proofread the manuscript; Haider KH contributed by providing critical feedback, helped shape the research, planning, and prepared the final manuscript for submission.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Khawaja Husnain Haider, BSc, BPharm, MPharm, PhD, KOSEF Fellow, Professor, Department of Basic Sciences, Sulaiman Alrajhi Medical School, PO Box 777, Al Bukairiyah 51941, Saudi Arabia. khhaider@gmail.com

Received: September 5, 2025
Revised: November 17, 2025
Accepted: January 27, 2026
Published online: July 26, 2026
Processing time: 320 Days and 9.6 Hours

Core Tip

Core Tip: This paper reviews advancements in the treatment and management of heart failure through cell-free therapies, including mesenchymal stem cell-derived secretomes and exosomes that deliver an array of bioactive molecules and participate in the repair process. The seven primary modules, which explain the reparative and regenerative potential of secretome and exosomes, have been discussed in the context of mechanistic understanding, drawing on published data from experimental and clinical settings that act on the myocardium to achieve the therapeutic benefits of the treatment.